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对 COVID-19 大流行期间免疫实践咨询委员会的反思。

Reflections on the Advisory Committee on Immunization Practices During the COVID-19 Pandemic.

机构信息

Departments of Pediatric and Epidemiology and Prevention (KA Poehling), Center for Vaccines at the Extremes of Aging, Wake Forest University School of Medicine, Winston-Salem, NC.

Department of Pediatrics (GM Lee), Stanford University School of Medicine, Calif.

出版信息

Acad Pediatr. 2024 Sep-Oct;24(7):1038-1046. doi: 10.1016/j.acap.2024.06.019. Epub 2024 Jul 6.

Abstract

Pediatricians and primary care providers serve an important role in building trust with families and communities. To support the critical role of front-line providers, this perspective seeks to reflect on the work of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices to support COVID-19 pandemic response efforts. Although Advisory Committee on Immunization Practice (ACIP) recommends vaccines for all age groups, this perspective focuses on the pediatric lens and is tailored to Academic Pediatrics. ACIP adapted from in-person meetings 3 times yearly to virtual meetings on an emergency basis to ensure a thorough review and presentation of all the components of the evidence to recommendation framework, including explicit consideration of equity in the decision-making process. The need for diverse enrollment in clinical trials was highlighted as critical for supporting recommendations and enhancing trust. Near real-time vaccine safety surveillance was implemented at scale and emphasized the importance of collaboration between federal partners engaged in vaccine safety in the United States and extended to other countries with similar safety surveillance systems to enable early recognition and response to safety concerns. A key equity opportunity for future pandemics is to shorten the time between vaccines being available for adults and young children.

摘要

儿科医生和初级保健提供者在与家庭和社区建立信任方面发挥着重要作用。为了支持一线提供者的关键作用,本观点旨在反思疾病预防控制中心免疫实践咨询委员会在支持 COVID-19 大流行应对工作中的工作。虽然免疫实践咨询委员会(ACIP)建议为所有年龄段的人接种疫苗,但本观点侧重于儿科视角,并针对学术儿科学量身定制。ACIP 每年从 3 次面对面会议改为紧急情况下的虚拟会议,以确保对证据到建议框架的所有组成部分进行彻底审查和介绍,包括在决策过程中明确考虑公平性。强调了在临床试验中进行多样化招募的必要性,这对于支持建议和增强信任至关重要。近实时疫苗安全监测大规模实施,并强调了参与美国疫苗安全的联邦合作伙伴之间合作的重要性,并扩展到具有类似安全监测系统的其他国家,以实现对安全问题的早期识别和响应。未来大流行的一个关键公平机会是缩短成人和幼儿可用疫苗之间的时间。

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