MMWR Morb Mortal Wkly Rep. 2021 Jan 1;69(5152):1657-1660. doi: 10.15585/mmwr.mm695152e2.
The first vaccines for prevention of coronavirus disease 2019 (COVID-19) in the United States were authorized for emergency use by the Food and Drug Administration (FDA) (1) and recommended by the Advisory Committee on Immunization Practices (ACIP) in December 2020.* However, demand for COVID-19 vaccines is expected to exceed supply during the first months of the national COVID-19 vaccination program. ACIP advises CDC on population groups and circumstances for vaccine use. On December 1, ACIP recommended that 1) health care personnel and 2) residents of long-term care facilities be offered COVID-19 vaccination first, in Phase 1a of the vaccination program (2). On December 20, 2020, ACIP recommended that in Phase 1b, vaccine should be offered to persons aged ≥75 years and frontline essential workers (non-health care workers), and that in Phase 1c, persons aged 65-74 years, persons aged 16-64 years with high-risk medical conditions, and essential workers not recommended for vaccination in Phase 1b should be offered vaccine.** These recommendations for phased allocation provide guidance for federal, state, and local jurisdictions while vaccine supply is limited. In its deliberations, ACIP considered scientific evidence regarding COVID-19 epidemiology, ethical principles, and vaccination program implementation considerations. ACIP's recommendations for COVID-19 vaccine allocation are interim and might be updated based on changes in conditions of FDA Emergency Use Authorization, FDA authorization for new COVID-19 vaccines, changes in vaccine supply, or changes in COVID-19 epidemiology.
美国食品和药物管理局(FDA)于 2020 年 12 月首次授权紧急使用用于预防 2019 年冠状病毒病(COVID-19)的疫苗*,同时免疫实践咨询委员会(ACIP)也推荐使用这些疫苗。然而,在全国 COVID-19 疫苗接种计划的头几个月,预计对 COVID-19 疫苗的需求将超过供应。ACIP 就疫苗使用的人群和情况向 CDC 提供建议。2020 年 12 月 1 日,ACIP 建议 1)医护人员和 2)长期护理机构居民首先接种 COVID-19 疫苗,这是疫苗接种计划 1a 阶段的内容(2)。2020 年 12 月 20 日,ACIP 建议在 1b 阶段,为年龄≥75 岁的人群和一线基本工作人员(非医护人员)提供疫苗;在 1c 阶段,为 65-74 岁的人群、年龄 16-64 岁且具有高危医疗条件的人群以及不建议在 1b 阶段接种疫苗的基本工作人员提供疫苗**。这些分阶段分配的建议为联邦、州和地方司法管辖区在疫苗供应有限的情况下提供了指导。在审议过程中,ACIP 考虑了 COVID-19 流行病学、伦理原则和疫苗接种计划实施方面的科学证据。ACIP 对 COVID-19 疫苗分配的建议是临时性的,可能会根据 FDA 紧急使用授权的条件变化、FDA 对新 COVID-19 疫苗的授权、疫苗供应的变化或 COVID-19 流行病学的变化进行更新。