College of Computer Science, Sichuan Normal University, Chengdu, 610101, China.
School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Sci Rep. 2024 Jul 8;14(1):15636. doi: 10.1038/s41598-024-64099-0.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized primarily by cognitive impairment. The motivation of this paper is to explore the impact of the visual information transmission pathway (V-H pathway) on AD, and the following feature were observed: Hemoglobin expression on the V-H pathway becomes dysregulated as AD occurs so as to the pathway becomes dysfunctional. According to the feature, the following conclusion was proposed: As AD occurs, abnormal tau proteins penetrate bloodstream and arrive at the brain regions of the pathway. Then the tau proteins or other toxic substances attack hemoglobin molecules. Under the attack, hemoglobin expression becomes more dysregulated. The dysfunction of V-H pathway has an impact on early symptoms of AD, such as spatial recognition disorder and face recognition disorder.
阿尔茨海默病（AD）是一种以认知障碍为主要特征的神经退行性疾病。本文的研究动机是探索视觉信息传递途径（V-H 途径）对 AD 的影响，并观察到以下特征：随着 AD 的发生，V-H 途径上的血红蛋白表达失调，导致途径功能障碍。根据这一特征，提出以下结论：随着 AD 的发生，异常的 tau 蛋白穿透血液到达途径的大脑区域。然后，tau 蛋白或其他有害物质攻击血红蛋白分子。在攻击下，血红蛋白表达变得更加失调。V-H 途径的功能障碍会对 AD 的早期症状产生影响，如空间识别障碍和人脸识别障碍。
