Doherty Monica, Foley Kitty-Rose, Schloss Janet
Faculty of Health, National Centre for Naturopathic Medicine, Southern Cross University, 1 Military Road, Lismore, NSW, 2480, Australia.
Faculty of Health, Southern Cross University, Gold Coast, Qld, 4225, Australia.
J Autism Dev Disord. 2024 Jul 8. doi: 10.1007/s10803-024-06449-5.
Complementary and Alternative Medicine (CAM) is a therapeutic option currently used by autistic people with continued interest and uptake. There remains limited evidence regarding the efficacy of CAM use in autism. The aim of this systematic review is to comprehensively review published clinical trials to explore the efficacy of CAM in autism. A systematic literature review of available research published from June 2013 to March 2023 was conducted. Our literature search identified 1826 eligible citations, and duplications removed (n = 694) with 102 articles eligible for title/abstract screening. After full text review, 39 studies were included. The results of this systematic review identified that for autistic people, vitamin and mineral supplements may only be of benefit if there is a deficiency. The results also found that the main interventions used were dietary interventions and nutraceuticals, including targeted supplements, vitamins and minerals, omega 3 s and prebiotics, probiotics and digestive enzymes. The evidence does not support some of the most frequently utilised dietary interventions, such as a Gluten Free Casein Free (GFCF) diet, and the use of targeted nutraceutical supplements may be of benefit, but more conclusive research is still required to direct safe and effective treatment.
补充与替代医学（CAM）是目前自闭症患者持续感兴趣并采用的一种治疗选择。关于自闭症患者使用补充与替代医学的疗效，证据仍然有限。本系统评价的目的是全面回顾已发表的临床试验，以探讨补充与替代医学在自闭症中的疗效。对2013年6月至2023年3月发表的现有研究进行了系统的文献综述。我们的文献检索确定了1826条合格引文，去除重复项（n = 694）后，有102篇文章符合标题/摘要筛选条件。经过全文审查，纳入了39项研究。本系统评价的结果表明，对于自闭症患者，维生素和矿物质补充剂可能只有在存在缺乏的情况下才有益处。结果还发现，主要使用的干预措施是饮食干预和营养保健品，包括靶向补充剂、维生素和矿物质、ω-3脂肪酸以及益生元、益生菌和消化酶。证据不支持一些最常用的饮食干预措施，如无麸质无酪蛋白（GFCF）饮食，靶向营养保健品补充剂的使用可能有益，但仍需要更具结论性的研究来指导安全有效的治疗。
