Ma Kai-Xian, Hong Chuan-Ming, Yan Jiang-Min, Li Qing-Hua, Liu Tang-Lin
Chongqing Key Laboratory of Soft-Matter Materials Manufacturing, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
Chem Commun (Camb). 2024 Jul 23;60(60):7753-7756. doi: 10.1039/d4cc02458c.
An efficient cyclization for the synthesis of 1,2,4,5-tetra-substituted benzenes copper catalyzed dimerization of γ,δ-unsaturated ketones has been described. This one-pot procedure employs the γ,δ-unsaturated ketones as the sole substrate with multiple C-C bond formation. This protocol features broad substrate scope and provides a facile and robust method to construct polysubstituted benzene derivatives under mild conditions.
已报道了一种用于合成1,2,4,5-四取代苯的有效环化反应——铜催化的γ,δ-不饱和酮二聚化反应。该一锅法以γ,δ-不饱和酮作为唯一底物，可形成多个碳-碳键。该方法具有广泛的底物范围，为在温和条件下构建多取代苯衍生物提供了一种简便且可靠的方法。
