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一例成年髓母细胞瘤伴多发肺转移瘤病例报告及文献复习

An Adult Case of Medulloblastoma with Multiple Lung Metastatic Lesions-Case Report and Literature Review.

作者信息

Azab Mohammed A

机构信息

Cairo University Hospital/University of Utah, Cleveland Clinic Foundation, Cleveland, Ohio, United States.

出版信息

Asian J Neurosurg. 2024 May 27;19(2):286-289. doi: 10.1055/s-0044-1787080. eCollection 2024 Jun.

DOI:10.1055/s-0044-1787080
PMID:38974448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11226244/
Abstract

Medulloblastoma (MB) cerebelli is a common brain tumor of the childhood. MB commonly spreads through cerebrospinal fluid; however, there are several reported cases of extracranial spread. The most common sites of extracranial metastasis are bones and bone marrow followed by peritoneum, liver, and lungs. Here, we report a case of pulmonary metastatic lesions of adult cerebellar MB that were discovered 1 year after the primary surgical treatment. We also tried to highlight similar reported cases in the literature.

摘要

小脑髓母细胞瘤（MB）是儿童期常见的脑肿瘤。MB通常通过脑脊液扩散；然而，有几例颅外扩散的报道病例。颅外转移最常见的部位是骨骼和骨髓，其次是腹膜、肝脏和肺部。在此，我们报告一例成人小脑MB肺转移瘤病例，该病例在初次手术治疗1年后被发现。我们还试图强调文献中报道的类似病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/c6e61c873a5c/10-1055-s-0044-1787080-i2310020-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/35ddafb666b3/10-1055-s-0044-1787080-i2310020-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/b13f809931b2/10-1055-s-0044-1787080-i2310020-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/c6e61c873a5c/10-1055-s-0044-1787080-i2310020-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/35ddafb666b3/10-1055-s-0044-1787080-i2310020-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/b13f809931b2/10-1055-s-0044-1787080-i2310020-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f937/11226244/c6e61c873a5c/10-1055-s-0044-1787080-i2310020-3.jpg

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本文引用的文献

1
Medulloblastoma: optimizing care with a multidisciplinary approach.髓母细胞瘤：采用多学科方法优化治疗
J Multidiscip Healthc. 2019 Apr 30;12:335-347. doi: 10.2147/JMDH.S167808. eCollection 2019.
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CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015.CBTRUS统计报告：2011 - 2015年美国原发性脑肿瘤及其他中枢神经系统肿瘤诊断情况
Neuro Oncol. 2018 Oct 1;20(suppl_4):iv1-iv86. doi: 10.1093/neuonc/noy131.
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A case of molecularly profiled extraneural medulloblastoma metastases in a child.
一名儿童发生分子特征分析的神经外髓母细胞瘤转移病例。
BMC Med Genet. 2018 Jan 17;19(1):10. doi: 10.1186/s12881-018-0526-8.
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Supratentorial metastasis of medulloblastoma in adults.成人髓母细胞瘤的幕上转移
Asian J Neurosurg. 2016 Jul-Sep;11(3):320. doi: 10.4103/1793-5482.149993.
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Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum.一名成年患者发生髓母细胞瘤并出现晚期纵隔神经外转移
J Investig Med High Impact Case Rep. 2014 Apr 17;2(2):2324709614532798. doi: 10.1177/2324709614532798. eCollection 2014 Apr-Jun.
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Incidence of medulloblastoma in Canadian children.加拿大儿童髓母细胞瘤的发病率。
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Curr Opin Neurol. 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1.
8
Adult medulloblastoma comprises three major molecular variants.成人髓母细胞瘤包含三个主要的分子亚型。
J Clin Oncol. 2011 Jul 1;29(19):2717-23. doi: 10.1200/JCO.2011.34.9373. Epub 2011 May 31.
9
Local control after craniospinal irradiation, intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma.颅脊髓放疗后、调强放疗加化疗治疗儿童髓母细胞瘤的局部控制。
Cancer. 2011 Feb 1;117(3):635-41. doi: 10.1002/cncr.25601. Epub 2010 Sep 15.
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Prognostic factors after extraneural metastasis of medulloblastoma.成神经管细胞瘤颅外转移后的预后因素。
Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):72-8. doi: 10.1016/j.ijrobp.2009.07.1729. Epub 2010 Feb 3.