Whalen R G
J Exp Biol. 1985 Mar;115:43-53. doi: 10.1242/jeb.115.1.43.
Myosin is a major component of skeletal muscle and it plays a central role in determining the physiological performance of adult tissue. Developing muscles contain myosin molecules which are different from the adult forms, and these isoenzymes have been found to be characteristic markers of the diverse physiological and pathological states of muscle tissue. The differences between these isoenzymes may be demonstrated by protein chemical, immunochemical and genetic evidence. The study of the sequential transitions between isoenzymes represents a means for characterizing the dynamic nature of muscle development, and neuronal and hormonal influences have been identified which contribute to the regulation of these transitions. The perspectives for future work include genetic studies, elucidation of the pathways relating extracellular signals to changes in gene expression, and the possibility that studies of myosin isoenzymes might further understanding of muscle pathology.
肌球蛋白是骨骼肌的主要成分，在决定成体组织的生理性能方面发挥着核心作用。发育中的肌肉含有与成体形式不同的肌球蛋白分子，并且已发现这些同工酶是肌肉组织各种生理和病理状态的特征性标志物。这些同工酶之间的差异可通过蛋白质化学、免疫化学和遗传学证据来证明。对同工酶之间顺序转变的研究是表征肌肉发育动态性质的一种手段，并且已确定神经元和激素影响有助于调节这些转变。未来工作的前景包括遗传学研究、阐明将细胞外信号与基因表达变化联系起来的途径，以及肌球蛋白同工酶研究可能进一步加深对肌肉病理学理解的可能性。
