Sruthi Rachabattuni S, Sarita P, Marandi Satyabhama, Nayak Sibananda, Pati Tapasi
Dept of O&G, Maharaja Institute Of Medical Sciences, Vizianagaram, Andhra Pradesh India.
Dept of O&G, IMS And Sum Hospital, Bhubaneswar, Odisha India.
J Obstet Gynaecol India. 2024 Jun;74(3):231-235. doi: 10.1007/s13224-023-01919-9. Epub 2024 Jan 19.
Hypertensive disorder of pregnancy is a mysterious condition. Even after extensive research, it is associated with high maternal as well as perinatal mortality and morbidity. The origin of hypertension in pregnancy is thought to be lying in the placenta. -hCG and PAPP-A are glycoproteins produced from placenta. Therefore, these values are reported to be altered in hypertensive disorders of pregnancy.
To determine the predictive value of early trimester serum β-hCG and PAPP-A levels for the development of hypertensive disorders of pregnancy.
This is a prospective cohort study conducted at IMS and SUM Hospital, Bhubaneswar. Maternal serum -hCG and PAPP-A levels were measured in all the singleton pregnant women at 11 + 0-13 + 6 weeks. All these women were followed up till delivery to find out the development of hypertension. The outcome was matched with their respective biochemical markers and analyzed.
Mean value for maternal serum -hCG of the study population was found to be 48.95 ng/ml with a range of 2-210 ng/ml. Hence, maternal serum -hCG value during 11-13 weeks of pregnancy shows no correlation with the development of HDP later in pregnancy. The mean value of maternal serum -hCG for women who developed HDP and those who did not develop the pathology was 48.13 ng/ml and 49.78 ng/ml, respectively ( = 0.61). Mean value of serum PAPP-A for the normotensive group was found to be 5.12 mIU/ml and 3.76 mIU/ml for women who developed HDP ( < 0.01).
Low maternal serum PAPP-A determined at 11 + 0-13 + 6 weeks has a better predictive value for the development of hypertensive disorders in pregnancy than -hCG.
妊娠期高血压疾病是一种神秘的病症。即便经过广泛研究，它仍与高孕产妇及围产期死亡率和发病率相关。妊娠期高血压的起源被认为与胎盘有关。β - 人绒毛膜促性腺激素（β - hCG）和妊娠相关血浆蛋白A（PAPP - A）是由胎盘产生的糖蛋白。因此，据报道这些值在妊娠期高血压疾病中会发生改变。
确定孕早期血清β - hCG和PAPP - A水平对妊娠期高血压疾病发生的预测价值。
这是一项在布巴内斯瓦尔的IMS和SUM医院进行的前瞻性队列研究。在所有单胎孕妇孕11⁺⁰至13⁺⁶周时测量其母血清β - hCG和PAPP - A水平。所有这些女性均随访至分娩，以了解高血压的发生情况。将结果与其各自的生化标志物进行匹配并分析。
研究人群母血清β - hCG的平均值为48.95 ng/ml，范围为2至210 ng/ml。因此，妊娠11至13周期间母血清β - hCG值与后期妊娠高血压疾病（HDP）的发生无相关性。发生HDP的女性和未发生该病症的女性母血清β - hCG的平均值分别为48.13 ng/ml和49.78 ng/ml（P = 0.61）。血压正常组血清PAPP - A的平均值为5.12 mIU/ml，发生HDP的女性为3.76 mIU/ml（P < 0.01）。
孕11⁺⁰至13⁺⁶周时测定的低母血清PAPP - A对妊娠期高血压疾病发生的预测价值优于β - hCG。
