Research and Development, Ciro+, Horn, the Netherlands.
NUTRIM, Institute of Nutrition and Translational Research in Metabolism, University Maastricht, Maastricht, the Netherlands.
Int J Chron Obstruct Pulmon Dis. 2024 Jul 2;19:1561-1578. doi: 10.2147/COPD.S458324. eCollection 2024.
Lung hyperinflation (LH) is a common clinical feature in patients with chronic obstructive pulmonary disease (COPD). It results from a combination of reduced elastic lung recoil as a consequence of irreversible destruction of lung parenchyma and expiratory airflow limitation. LH is an important determinant of morbidity and mortality in COPD, partially independent of the degree of airflow limitation. Therefore, reducing LH has become a major target in the treatment of COPD over the last decades. Advances were made in the diagnostics of LH and several effective interventions became available. Moreover, there is increasing evidence suggesting that LH is not only an isolated feature in COPD but rather part of a distinct clinical phenotype that may require a more integrated management. This narrative review focuses on the pathophysiology and adverse consequences of LH, the assessment of LH with lung function measurements and imaging techniques and highlights LH as a treatable trait in COPD. Finally, several suggestions regarding future studies in this field are made.
肺过度充气（LH）是慢性阻塞性肺疾病（COPD）患者的常见临床特征。它是由于肺实质不可逆破坏导致的弹性回缩力降低和呼气气流受限共同作用的结果。LH 是 COPD 发病率和死亡率的一个重要决定因素，部分独立于气流受限程度。因此，在过去几十年中，降低 LH 已成为 COPD 治疗的主要目标。在 LH 的诊断方面取得了进展，并且出现了几种有效的干预措施。此外，越来越多的证据表明，LH 不仅是 COPD 的一个孤立特征，而是一种独特的临床表型的一部分，可能需要更综合的管理。这篇叙述性综述重点介绍了 LH 的病理生理学和不良后果，以及肺功能测量和影像学技术评估 LH 的方法，并强调了 LH 作为 COPD 可治疗特征的重要性。最后，针对该领域的未来研究提出了一些建议。
