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Long-term bevacizumab is safe and effective in managing small bowel angioectasias bleeding refractory to conventional treatments: a case report.

作者信息

Compare Debora, Sgamato Costantino, Rocco Alba, Minieri Stefano, Cinque Sofia, Giordano Flaviana, Nardone Gerardo

机构信息

Department of Clinical Medicine and Surgery, Gastroenterology, University Federico II, Naples, Italy.

出版信息

Gastroenterol Rep (Oxf). 2024 Jul 6;12:goae070. doi: 10.1093/gastro/goae070. eCollection 2024.

DOI:10.1093/gastro/goae070
PMID:38974879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11227363/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0974/11227363/48b30aa8b2ea/goae070f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0974/11227363/48b30aa8b2ea/goae070f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0974/11227363/48b30aa8b2ea/goae070f1.jpg

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1
Long-term bevacizumab is safe and effective in managing small bowel angioectasias bleeding refractory to conventional treatments: a case report.长期使用贝伐单抗治疗常规治疗难治性小肠血管扩张出血安全有效：一例报告
Gastroenterol Rep (Oxf). 2024 Jul 6;12:goae070. doi: 10.1093/gastro/goae070. eCollection 2024.
2
Small Intestinal Angioectasias Are Not Randomly Distributed in the Small Bowel and Most May Be Reached by Push Enteroscopy.小肠血管扩张症并非随机分布于小肠，多数可通过推进式小肠镜检查到达。
J Clin Gastroenterol. 2016 Aug;50(7):561-5. doi: 10.1097/MCG.0000000000000425.
3
High short-term rebleeding rate in patients undergoing a second endoscopic therapy for small-bowel angioectasias after recurrent bleeding.复发性出血后接受小肠血管扩张症二次内镜治疗的患者短期再出血率较高。
Rev Esp Enferm Dig. 2018 Feb;110(2):88-93. doi: 10.17235/reed.2017.4872/2017.
4
Predictors and characteristics of angioectasias in patients with obscure gastrointestinal bleeding identified by video capsule endoscopy.经视频胶囊内镜检查确诊的不明原因消化道出血患者血管扩张的预测因素及特征
United European Gastroenterol J. 2017 Dec;5(8):1129-1135. doi: 10.1177/2050640617704366. Epub 2017 Apr 7.
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Distribution of bleeding gastrointestinal angioectasias in a Western population.西方人群中出血性胃肠道血管扩张症的分布。
World J Gastroenterol. 2012 Nov 21;18(43):6235-9. doi: 10.3748/wjg.v18.i43.6235.
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Mapping the distribution of small bowel angioectasias.绘制小肠血管扩张症的分布图。
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Multifocal Small Bowel Angioectasias: Managed with Innovative, Nonresectional Surgical Procedure.多灶性小肠血管扩张症：采用创新的非切除性手术方法进行治疗。
Surg J (N Y). 2022 Aug 16;8(3):e169-e173. doi: 10.1055/s-0042-1744151. eCollection 2022 Jul.
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Management of small bowel angioectasias diagnosed during video capsule endoscopy.视频胶囊内镜检查时诊断出的小肠血管扩张症的管理
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Is it possible to predict the presence of intestinal angioectasias?是否有可能预测肠道血管扩张的存在？
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Small Bowel Angioectasias Rebleeding and the Identification of Higher Risk Patients.小肠血管扩张再出血和高危患者的识别。
Dig Dis Sci. 2021 Jan;66(1):175-180. doi: 10.1007/s10620-020-06137-1. Epub 2020 Feb 18.

本文引用的文献

1
Intravenous Bevacizumab Reduces Transfusion Requirements and Endoscopic Interventions in Patients With Gastric Antral Vascular Ectasia and Small Bowel Angioectasia.静脉注射贝伐单抗可减少胃窦血管扩张症和小肠血管扩张症患者的输血需求及内镜干预。
Gastroenterology. 2020 Mar;158(4):1162-1163.e4. doi: 10.1053/j.gastro.2019.11.027. Epub 2019 Nov 21.
2
Risk of bleeding associated with antiangiogenic monoclonal antibodies bevacizumab and ramucirumab: a meta-analysis of 85 randomized controlled trials.抗血管生成单克隆抗体贝伐单抗和雷莫西尤单抗相关的出血风险：85项随机对照试验的荟萃分析
Onco Targets Ther. 2018 Aug 21;11:5059-5074. doi: 10.2147/OTT.S166151. eCollection 2018.
3
Pharmacological treatment of gastrointestinal bleeding due to angiodysplasias: A position paper of the Italian Society of Gastroenterology (SIGE).
意大利胃肠病学会（SIGE）关于血管发育不良引起的胃肠道出血的药物治疗：立场文件。
Dig Liver Dis. 2018 Jun;50(6):542-548. doi: 10.1016/j.dld.2018.02.004. Epub 2018 Feb 15.
4
Effect of systemic bevacizumab in severe hereditary hemorrhagic telangiectasia associated with bleeding.全身性贝伐单抗对与出血相关的严重遗传性出血性毛细血管扩张症的疗效。
Am J Hematol. 2016 Jun;91(6):E313-4. doi: 10.1002/ajh.24367. Epub 2016 Apr 28.
5
Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial.长效生长抑素类似物对难治性小肠血管发育不良患者具有显著的有益作用：来自概念验证、开放标签、单中心试验的结果。
United European Gastroenterol J. 2016 Feb;4(1):70-6. doi: 10.1177/2050640614559121. Epub 2015 Nov 5.
6
The natural history of small bowel angiodysplasia.小肠血管发育异常的自然病史。
Scand J Gastroenterol. 2016;51(4):393-9. doi: 10.3109/00365521.2015.1102317. Epub 2015 Nov 5.
7
Hereditary hemorrhagic telangiectasia treated with low dose intravenous bevacizumab.低剂量静脉注射贝伐单抗治疗遗传性出血性毛细血管扩张症。
Blood Res. 2014 Sep;49(3):192-5. doi: 10.5045/br.2014.49.3.192. Epub 2014 Sep 25.
8
Long acting release-octreotide as "rescue" therapy to control angiodysplasia bleeding: A retrospective study of 98 cases.长效释放奥曲肽作为“挽救”疗法控制血管发育异常出血：98例回顾性研究
Dig Liver Dis. 2014 Aug;46(8):688-94. doi: 10.1016/j.dld.2014.04.011. Epub 2014 Jun 2.
9
The changing face of hospitalisation due to gastrointestinal bleeding and perforation.由于胃肠道出血和穿孔导致的住院情况正在发生变化。
Aliment Pharmacol Ther. 2011 Mar;33(5):585-91. doi: 10.1111/j.1365-2036.2010.04563.x. Epub 2011 Jan 5.
10
Pharmacological therapy of vascular malformations of the gastrointestinal tract.胃肠道血管畸形的药物治疗
Can J Gastroenterol. 2006 Mar;20(3):171-8. doi: 10.1155/2006/859435.