Bartko Ewa Anna, Elberling Jesper, Mosbech Holger
Gentofte Hospital, Skin and Allergy Department, Allergy Clinic, Hellerup, Denmark.
World Allergy Organ J. 2024 Jun 13;17(6):100915. doi: 10.1016/j.waojou.2024.100915. eCollection 2024 Jun.
The global application of the skin prick test (SPT) is attributed to the low costs, easy execution, and approach. Still, the healthcare professionals' technique and the lancet shape may challenge the standardization of the method. Thus, we investigated the influence of the shape of the lancet and the applied weight on the wheal size of SPT. Two allergic and one non-allergic individual were tested with allergens ( and ) and histamine solution (positive control), respectively. Horizontally (HS) and diagonally (DS) shouldered lancets with the same tip length (1 mm) were tested under two different conditions: either 60 g or 120 g weight pressure. The wheal size induced by the 4 different combinations was measured. The higher-weight device (120 g) induced a significantly larger and less variable wheal response with the tested allergens and histamine. However, the shape of the lancet affected the wheal size more than the applied weight. The least variable response was measured to histamine for the horizontal-shouldered lancet combined with the higher weight, whereas the same lancet with the lower weight resulted in a significant number of false negative results.
皮肤点刺试验（SPT）在全球范围内的应用归因于其成本低、操作简便以及[此处原文缺失相关内容]。然而，医护人员的技术以及采血针的形状可能会对该方法的标准化提出挑战。因此，我们研究了采血针形状和施加的重量对皮肤点刺试验风团大小的影响。分别对两名过敏个体和一名非过敏个体进行变应原（[此处原文缺失相关内容]）和组胺溶液（阳性对照）测试。在两种不同条件下测试了尖端长度相同（1毫米）的水平肩部（HS）和对角肩部（DS）采血针：重量压力分别为60克或120克。测量了由4种不同组合引起的风团大小。较重重量的装置（120克）在用测试的变应原和组胺测试时，引起的风团反应明显更大且变异性更小。然而，采血针的形状对风团大小的影响大于施加的重量。对于水平肩部采血针与较重重量相结合的情况，对组胺的反应变异性最小，而相同的采血针与较轻重量相结合则导致大量假阴性结果。
