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2
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Oxytocin: Not "just a female hormone": A very special issue and a very special molecule.催产素：并非“只是一种女性激素”：一个非常特殊的议题和一种非常特殊的分子。
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本文引用的文献

1
Intranasal Oxytocin for Obesity.用于治疗肥胖症的鼻内催产素
NEJM Evid. 2024 May;3(5):EVIDoa2300349. doi: 10.1056/EVIDoa2300349. Epub 2024 Apr 23.
2
Close encounters with oxytocin.与催产素的亲密接触。
Compr Psychoneuroendocrinol. 2023 Jun 29;15:100189. doi: 10.1016/j.cpnec.2023.100189. eCollection 2023 Aug.
3
Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial.对精氨酸加压素缺乏症（中枢性尿崩症）患者进行 MDMA 激发试验时的催产素反应：一项单中心、病例对照研究，包含嵌套、随机、双盲、安慰剂对照交叉试验。
Lancet Diabetes Endocrinol. 2023 Jul;11(7):454-464. doi: 10.1016/S2213-8587(23)00120-1. Epub 2023 May 13.
4
Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior.低催产素水平与主要表现为限制但不暴食/清除行为的神经性厌食症中更明显的精神病理学广泛相关。
Front Endocrinol (Lausanne). 2023 Jan 31;13:1049541. doi: 10.3389/fendo.2022.1049541. eCollection 2022.
5
Novel Long-Acting Oxytocin Analog with Increased Efficacy in Reducing Food Intake and Body Weight.新型长效催产素类似物，可有效减少食物摄入和体重。
Int J Mol Sci. 2022 Sep 24;23(19):11249. doi: 10.3390/ijms231911249.
6
A randomized, double-blind, placebo-controlled clinical trial of 8-week intranasal oxytocin administration in adults with obesity: Rationale, study design, and methods.一项为期 8 周的肥胖成人鼻腔内给予催产素的随机、双盲、安慰剂对照临床试验：原理、研究设计和方法。
Contemp Clin Trials. 2022 Nov;122:106909. doi: 10.1016/j.cct.2022.106909. Epub 2022 Sep 7.
7
Impact of Magnesium on Oxytocin Receptor Function.镁对催产素受体功能的影响。
Pharmaceutics. 2022 May 21;14(5):1105. doi: 10.3390/pharmaceutics14051105.
8
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans.催产素对人类食欲调节、食物摄入和代谢的影响。
Int J Mol Sci. 2021 Jul 20;22(14):7737. doi: 10.3390/ijms22147737.
9
Oxytocin levels in response to pituitary provocation tests in healthy volunteers.健康志愿者垂体激发试验的反应中的催产素水平。
Eur J Endocrinol. 2021 Aug 3;185(3):355-364. doi: 10.1530/EJE-21-0346.
10
Biomarkers of Clinician Burnout.临床医生职业倦怠的生物标志物。
J Gen Intern Med. 2022 Feb;37(2):478-479. doi: 10.1007/s11606-021-06757-x. Epub 2021 Apr 26.

了解催产素在人体生理学和病理生理学中的作用：通往治疗方法之路。

Understanding oxytocin in human physiology and pathophysiology: A path towards therapeutics.

作者信息

Lawson Elizabeth A

机构信息

Neuroendocrine Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, 50 Staniford Street, Suite 750B, Boston, MA, 02114, USA.

出版信息

Compr Psychoneuroendocrinol. 2024 May 28;19:100242. doi: 10.1016/j.cpnec.2024.100242. eCollection 2024 Aug.

DOI:10.1016/j.cpnec.2024.100242
PMID:38974962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11225698/
Abstract

•Oxytocin is a multifaceted hypothalamic-pituitary hormone involved in energy homeostasis, mental health, and bone metabolism.•Oxytocin deficiency in energy deficit states and in hypopituitarism is associated with worse mental health and bone health.•Oxytocin modulates appetitive neurocircuitry, improves impulse control, and reduces food intake in humans.•Defining the oxytocin system in human physiology and pathophysiology could lead to novel therapeutic strategies.

摘要

•催产素是一种多方面的下丘脑 - 垂体激素，参与能量平衡、心理健康和骨代谢。

•能量缺乏状态和垂体功能减退时的催产素缺乏与较差的心理健康和骨骼健康有关。

•催产素调节食欲神经回路，改善冲动控制，并减少人类的食物摄入量。

•确定人类生理和病理生理学中的催产素系统可能会带来新的治疗策略。