Watanabe Norio, Itano Akira, Ando Motozumi, Kawahara Masami
Department of Pharmaceutical Sciences, School of Pharmacy, Aichi Gakuin University, Japan.
WALNUT PHARMACIES Inc., Japan.
J Rural Med. 2024 Jul;19(3):192-195. doi: 10.2185/jrm.2023-038. Epub 2024 Jul 1.
To investigate the laxative effect of reducing the number of daily doses of magnesium oxide (MgO), while maintaining the total daily dose of MgO in patients with good bowel movements. The retrospective analysis involved 11 patients with regular bowel movements who were prescribed MgO for constipation upon admission to a nursing care facility accompanied by home visits by a pharmacist. This investigation was conducted before and after reducing the number of daily doses from three to two, or from two to one, over a two-week period. The number of bowel movements was 7.6 ± 3.4 and 6.6 ± 4.0 times for two weeks before and after the change in dosage frequency, respectively. The difference was not statistically significant (=0.09). The Bristol Stool Form Scale was 3.9 ± 0.9 and 4.0 ± 0.9 two weeks before and after the change, respectively, which was not significant (=0.93). Two weeks after the change, the MgO regimen remained unchanged and no on-demand laxatives were administered. The results suggest that reducing the number of daily doses of MgO does not affect its laxative action.
为研究在保持每日氧化镁（MgO）总剂量不变的情况下，减少氧化镁每日服用剂量次数对排便正常患者的通便效果。回顾性分析纳入了11例排便规律的患者，这些患者在入住护理机构时因便秘被开具氧化镁处方，同时有药剂师进行家访。本研究在两周内将每日服用次数从三次减至两次，或从两次减至一次前后进行。剂量频率改变前后两周的排便次数分别为7.6±3.4次和6.6±4.0次。差异无统计学意义（P=0.09）。布里斯托大便分类法评分在改变前后两周分别为3.9±0.9和4.0±0.9，无显著差异（P=0.93）。改变两周后，氧化镁治疗方案保持不变，且未使用按需泻药。结果表明，减少氧化镁的每日服用次数不影响其通便作用。
