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用于自身免疫检测的多点免疫结合试验:对结缔组织疾病诊断和管理的评估

A multidot immunobinding assay for autoimmune testing: evaluation for the diagnosis and management of connective tissue diseases.

作者信息

Gordon J, Rosenthal M

出版信息

J Rheumatol. 1985 Apr;12(2):257-64.

PMID:3897533
Abstract

Multidot immunobinding assays were evaluated for applicability to connective tissue diseases. Four groups of human sera [(a) healthy, (b) miscellaneous diseases, (c) rheumatoid arthritis and (d) other connective tissue diseases] were used to obtain profiles comprising antibodies against DNA, various subcellular components and rheumatoid factor (RF). Qualitative correlation with standard tests for antinuclear factor and RF was shown. Statistically significant ranges of titer for groups (c) and (d) were obtained, and monitoring individual patients during the progression of disease was demonstrated.

摘要

对多点免疫结合测定法在结缔组织疾病中的适用性进行了评估。使用四组人血清((a)健康组、(b)杂病组、(c)类风湿性关节炎组和(d)其他结缔组织疾病组)来获取包含抗DNA、各种亚细胞成分和类风湿因子(RF)抗体的图谱。显示了与抗核因子和RF标准检测的定性相关性。获得了(c)组和(d)组具有统计学意义的滴度范围,并证明了在疾病进展过程中对个体患者的监测。

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