Busch C, Ljungman C, Heldin C M, Waskson E, Obrink B
Haemostasis. 1979;8(3-5):142-8. doi: 10.1159/000214306.
Vascular endothelial cells (EC) are non-thrombogenic. The basis for this property is still essentially unknown. This paper summarizes our previous studies on EC associated glycosaminoglycans and on the specific binding of heparin to EC and describes the preventive effect of heparin sulphate (HS) on platelet adhesion to collagen; attempts to affect the binding of platelets to EC by specific removal of endogenous HS were, however, unsuccessful. The possible importance of EC surface HS for interactions with coagulation factors is discussed.
血管内皮细胞（EC）具有抗血栓形成的特性。然而，这种特性的基础基本上仍然未知。本文总结了我们之前关于内皮细胞相关糖胺聚糖以及肝素与内皮细胞特异性结合的研究，并描述了硫酸乙酰肝素（HS）对血小板黏附于胶原蛋白的预防作用；然而，通过特异性去除内源性HS来影响血小板与内皮细胞结合的尝试并未成功。本文还讨论了内皮细胞表面HS在与凝血因子相互作用中的潜在重要性。
