前列环素、血栓素A2在止血和血栓形成中的相互作用
Prostacyclin, thromboxane A2 interactions in haemostasis and thrombosis.
作者信息
Moncada S, Amezcua J L
出版信息
Haemostasis. 1979;8(3-5):252-65. doi: 10.1159/000214316.
PMID:389758
Abstract
Prostacyclin and thromboxane A2 are products of arachidonic acid which play a role in the regulation of haemostatic plug and thrombus formation. Aspirin inhibits the synthesis of both compounds but is more active in blocking TXA2 formation; based on this, aspirin is suggested to have an anti-thrombotic effect. Other possible approaches to the development of anti-thrombotic drugs are discussed.
摘要
前列环素和血栓素A2是花生四烯酸的产物，它们在止血栓和血栓形成的调节中发挥作用。阿司匹林抑制这两种化合物的合成，但在阻断血栓素A2形成方面更具活性；基于此，阿司匹林被认为具有抗血栓作用。文中还讨论了抗血栓药物研发的其他可能途径。
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