Moncada S
The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Philos Trans R Soc Lond B Biol Sci. 2006 May 29;361(1469):735-59. doi: 10.1098/rstb.2005.1775.
I would like to thank the Royal Society for inviting me to deliver the Croonian Lecture. In so doing, the Society is adding my name to a list of very distinguished scientists who, since 1738, have preceded me in this task. This is, indeed, a great honour. For most of my research career my main interest has been the understanding of the normal functioning of the blood vessel wall and the way this is affected in pathology. During this time, our knowledge of these subjects has grown to such an extent that many people now believe that the conquering of vascular disease is a real possibility in the foreseeable future. My lecture concerns the discovery of two substances, prostacyclin and nitric oxide. I would like to describe the moments of insight and some of the critical experiments that contributed significantly to the uncovering of their roles in vascular biology. The process was often adventurous, hence the title of this lecture. It is the excitement of the adventure that I would like to convey in the text that follows.
我要感谢皇家学会邀请我发表克罗尼安讲座。这样做，学会将我的名字加入了自1738年以来在此任务中先于我的非常杰出的科学家名单中。这确实是一项巨大的荣誉。在我的大部分研究生涯中，我的主要兴趣一直是了解血管壁的正常功能以及其在病理学中受到影响的方式。在此期间，我们对这些主题的了解已经发展到如此程度，以至于现在许多人认为在可预见的未来征服血管疾病是切实可行的。我的讲座涉及两种物质的发现，即前列环素和一氧化氮。我想描述一下那些顿悟时刻以及一些对揭示它们在血管生物学中的作用有重大贡献的关键实验。这个过程常常充满冒险，因此有了本次讲座的标题。我想在接下来的内容中传达这种冒险的兴奋之情。
