Ginsberg-Fellner F, Witt M E, Franklin B H, Yagihashi S, Toguchi Y, Dobersen M J, Rubinstein P, Notkins A L
JAMA. 1985 Sep 20;254(11):1469-72.
A longitudinal investigation was conducted from 1977 to 1984 on 178 families in which one or more of the children had insulin-dependent diabetes mellitus. Of 351 nondiabetic sibs followed up for an average of 54 months, ten have, thus far, become diabetic. Eight sibs were HLA identical to their diabetic proband and nine had HLA-DR3 and/or HLA-DR4. Islet cell surface antibody and islet cell cytoplasmic antibody were found from two to 74 months before the onset of clinical diabetes in 100% and 90%, respectively, of the children. A decrease in insulin secretion was observed in all of these children on entry into the study and was detected in the absence of elevated plasma glucose concentrations. The data suggest that the triad of HLA identity, pancreatic islet cell antibodies, and depressed insulin secretion identifies those sibs who are at high risk of developing insulin-dependent diabetes mellitus.
1977年至1984年，对178个家庭进行了一项纵向调查，这些家庭中有一个或多个孩子患有胰岛素依赖型糖尿病。在平均随访54个月的351名非糖尿病同胞中，到目前为止，有10人患了糖尿病。8名同胞与他们的糖尿病先证者HLA相同，9名具有HLA - DR3和/或HLA - DR4。在临床糖尿病发病前2至74个月，分别在100%和90%的儿童中发现了胰岛细胞表面抗体和胰岛细胞胞浆抗体。在进入研究时，所有这些儿童均观察到胰岛素分泌减少，且在血浆葡萄糖浓度未升高的情况下检测到。数据表明，HLA相同、胰岛细胞抗体和胰岛素分泌降低这三者共同确定了那些有患胰岛素依赖型糖尿病高风险的同胞。
