McArthur R G, Field L L, Yoon J W, Boyd N, Graham J M
Julia McFarlane Diabetes Research Unit, Faculty of Medicine, University of Calgary, Alberta, Canada.
Clin Invest Med. 1987 Sep;10(5):470-4.
A family is reported in which the mother and both of her children developed insulin-dependent diabetes mellitus between 9 and 19 months of age, reflecting the importance of heredity in the natural history of this disease. That overt complications of diabetes were not present in any of the individuals, and that blood sugars were maintained close to normal on relatively small amounts of exogenous insulin, suggests a protective function in these patients related to residual secretion of insulin by beta cells. Human lymphocyte antigen (HLA) typing in this family showed that, although the diabetic children had identical HLA types, neither the mother nor her children possessed the diabetes-associated antigen HLA-DR3 or HLA-DR4. This raises the possibility that selective loss of diabetes-susceptible fetuses (suggested to be responsible for the low risk of diabetic mothers producing diabetic offspring) may be influenced by the HLA type of the mother.
据报道，有一个家庭，母亲及其两个孩子在9至19个月大时均患上了胰岛素依赖型糖尿病，这反映出遗传因素在该疾病自然病程中的重要性。这些个体均未出现糖尿病的明显并发症，且使用相对少量的外源性胰岛素就能使血糖维持在接近正常的水平，这表明这些患者体内存在一种与β细胞胰岛素残余分泌相关的保护功能。对这个家庭进行的人类淋巴细胞抗原（HLA）分型显示，尽管患病儿童的HLA类型相同，但母亲及其孩子均不具备与糖尿病相关的抗原HLA - DR3或HLA - DR4。这就增加了一种可能性，即糖尿病易感胎儿的选择性丢失（有人认为这是糖尿病母亲生出糖尿病后代风险较低的原因）可能受母亲HLA类型的影响。
