头孢米诺在儿科领域的临床研究

[Clinical studies on cefminox in pediatric field].

作者信息

Sato T, Tasaki H, Ueda K, Kuroiwa T

出版信息

Jpn J Antibiot. 1985 Mar;38(3):784-90.

Abstract

Clinical studies on cefminox (CMNX, MT-141) were conducted and the following results were obtained. Twelve cases of bacterial infections were treated with CMNX with a satisfactory result of "excellent" in 9 and "good" in 3. Antibacterial activity was examined in 7 cases. Pathogenic organisms which were S. aureus, beta-Streptococcus, H. influenzae, S. pneumoniae and P. morganii were eradicated in all the cases. Mean maximum serum concentrations of CMNX after intravenous injection of 10, 20 and 40 mg/kg were 54.5 mcg/ml, 102.3 mcg/ml and 202.4 mcg/ml, respectively which were obtained 15 minutes after each injection. Mean half-lives of each dose group were 1.60, 1.13 and 1.51 hours, respectively. Mean urinary excretion rates of CMNX at 6 hours after intravenous injection in 10, 20, 30 and 40 mg/kg groups were 73.5%, 80.9%, 92.6% and 66.5%, respectively. Side effects were not observed clinically, but anemia in 1 case and eosinophilia in 2 cases were noted in laboratory examination.

摘要

开展了头孢米诺（CMNX，MT - 141）的临床研究，并获得了以下结果。12例细菌感染患者接受了CMNX治疗，9例结果为“优”，3例为“良”，疗效满意。对7例患者进行了抗菌活性检测。所有病例中的病原菌，即金黄色葡萄球菌、β - 链球菌、流感嗜血杆菌、肺炎链球菌和摩根氏菌均被根除。静脉注射10、20和40mg/kg后，CMNX的平均最大血清浓度分别为54.5mcg/ml、102.3mcg/ml和202.4mcg/ml，分别在每次注射后15分钟测得。各剂量组的平均半衰期分别为1.60、1.13和1.51小时。静脉注射10、20、30和40mg/kg组在6小时后的CMNX平均尿排泄率分别为73.5%、80.9%、92.6%和66.5%。临床未观察到副作用，但实验室检查发现1例贫血和2例嗜酸性粒细胞增多。