Haruta T, Kuroki S, Ohkura K, Kobayashi Y
Jpn J Antibiot. 1985 Mar;38(3):737-42.
A new antibiotic of cephamycin group, cefminox (CMNX, MT-141), was evaluated clinically in the treatment of bacterial infections in children. The following results were obtained. One case of lacunar tonsillitis (due to H. influenzae) and 5 cases of urinary tract infections (due to E. coli in 2 cases, mixed infection due to E. coli and E. faecalis in 1 case, due to K. pneumoniae in 1 case and causative organism was unknown in 1 case) were treated intravenously with CMNX at daily doses ranging from 58.1 to 122.7 mg/kg in 3 divided doses. One case in which the treatment was discontinued after 1 day because of rashes was excluded from assessment of efficacy. Among the remaining 5 cases, CMNX was found ineffective for 1 case of mixed infection due to E. coli and E. faecalis. However, in all of the other 4 cases excellent results were obtained. As side effects, rashes developed in 1 case and slight elevation in GOT in 1 case out of 6 cases. Blood levels following bolus intravenous injection of 20 mg/kg of CMNX were 68, 45, 27, 10.2 and 3.1 micrograms/ml at 1/2, 1, 2, 4 and 6 hours, respectively, with T 1/2 of 1.27 hours. The urinary recovery rate within the first 6 hours was 78.6%.
一种新型头孢霉素类抗生素头孢米诺（CMNX，MT - 141）用于治疗儿童细菌感染的临床评估。获得了以下结果。1例陷窝性扁桃体炎（由流感嗜血杆菌引起）和5例尿路感染（2例由大肠杆菌引起，1例由大肠杆菌和粪肠球菌混合感染引起，1例由肺炎克雷伯菌引起，1例病原体不明）采用头孢米诺静脉注射治疗，日剂量为58.1至122.7mg/kg，分3次给药。1例因出现皮疹在治疗1天后停药，该病例被排除在疗效评估之外。在其余5例中，发现头孢米诺对1例大肠杆菌和粪肠球菌混合感染无效。然而，在其他4例中均取得了良好效果。作为副作用，6例中有1例出现皮疹，1例谷草转氨酶轻度升高。静脉推注20mg/kg头孢米诺后，在1/2、1、2、4和6小时的血药浓度分别为68、45、27、10.2和3.1μg/ml，半衰期为1.27小时。前6小时的尿回收率为78.6%。
