Department of Materials Science and Engineering, The University of Texas at Arlington, Arlington, TX, USA.
Bone Muscle Research Center, The University of Texas at Arlington, Arlington, TX, USA.
Methods Mol Biol. 2024;2816:41-52. doi: 10.1007/978-1-0716-3902-3_5.
This chapter provides an overview of the diverse range of applications associated with nanoparticles. The application of nanoparticles in the medical field has garnered considerable attention due to their unique properties and versatile compositions. They have shown promise in the treatment of cancer, fungal and viral infections, and pain management. These systems provide numerous benefits, such as increased drug stability, improved bioavailability, and targeted delivery to specific tissues or cells. The objective of this chapter is to provide a brief analysis of the differences between nanoparticles and lipid particles, focusing particularly on the importance of nanoparticle size and composition in their interactions with lipids. Additionally, the applications of nanoparticles in lipid signaling will be discussed, considering the vital roles lipids play in cellular signaling pathways. Nanoparticles have shown immense potential in the regulation and control of medical pathways. In this case, we will focus on the manufacture of liposomes, a type of nanoparticle composed of lipids. The reason behind the extensive investigation into liposomes as drug delivery vehicles is their remarkable biocompatibility and adaptability. This section will provide insights into the methods and techniques employed for liposome formulation.
这一章提供了纳米粒子各种应用的概述。由于其独特的性质和多样的组成，纳米粒子在医学领域的应用引起了相当大的关注。它们在癌症、真菌和病毒感染以及疼痛管理的治疗中显示出了前景。这些系统提供了许多好处，如增加药物稳定性、提高生物利用度以及靶向递送到特定的组织或细胞。本章的目的是简要分析纳米粒子和脂质体之间的区别，特别关注纳米粒子大小和组成在与脂质相互作用中的重要性。此外，还将讨论纳米粒子在脂质信号中的应用，考虑到脂质在细胞信号通路中的重要作用。纳米粒子在医学途径的调节和控制方面显示出了巨大的潜力。在这种情况下，我们将重点关注脂质体的制造，脂质体是由脂质组成的一种纳米粒子。对脂质体作为药物递送载体进行广泛研究的原因是其显著的生物相容性和适应性。这一节将介绍脂质体制备中使用的方法和技术。
