Jiménez-Jiménez Carla, Manzano Miguel, Vallet-Regí María
Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid, UCM, Instituto Investigación Sanitaria Hospital 12 de Octubre, imas12, 28040 Madrid, Spain.
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
Biology (Basel). 2020 Nov 18;9(11):406. doi: 10.3390/biology9110406.
Nanoparticles designed for diagnosing and treating different diseases have impacted the scientific research in biomedicine, and are expected to revolutionize the clinic in the near future through a new area called nanomedicine. In the last few years, a new approach in this field has emerged: the use of cell membranes for coating nanoparticles in an attempt to mimic the ability of cells to interface and interact with physiological environments. Although such functions have been replicated through synthetic techniques, many research groups are now employing naturally derived cell membranes to coat different types of nanoparticles in an attempt to improve their performance for a wide range of applications. This review summarizes the literature on nanoparticles coated with cell membranes and, more importantly, aims at inspiring and encouraging new developments to this technology in the biomedical area.
设计用于诊断和治疗不同疾病的纳米颗粒已经对生物医学领域的科学研究产生了影响，并且有望在不久的将来通过一个名为纳米医学的新领域给临床带来变革。在过去几年中，该领域出现了一种新方法：利用细胞膜包覆纳米颗粒，试图模拟细胞与生理环境相互作用的能力。尽管这些功能已经通过合成技术得以复制，但现在许多研究小组正在采用天然来源的细胞膜来包覆不同类型的纳米颗粒，以期改善其在广泛应用中的性能。这篇综述总结了有关细胞膜包覆纳米颗粒的文献，更重要的是，旨在激发和鼓励该技术在生物医学领域的新发展。
