Li Qingxian, Zhang Xin, Jiang Song, Pang Wenjuan, Sun Ningxia
Reproductive Medicine Center, Second Affiliated Hospital of Naval Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.
Department of Medical Imaging, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Reprod Sci. 2025 Apr;32(4):1180-1189. doi: 10.1007/s43032-024-01642-4. Epub 2024 Jul 8.
This retrospective cohort study aimed to compare the clinical outcomes of patients with cesarean scar defect (CSD) undergoing frozen embryo transfer (FET) with or without hysteroscopic repair surgery. The study included 82 patients, with 48 patients in surgical group A (undergoing CSD repair) and 34 patients in surgical group B (undergoing hysteroscopic treatment for other uterine lesions). The results showed that patients in group A had a larger CSD volume and a different shape compared to group B. However, there was no significant difference in clinical pregnancy rates between the two groups. Additionally, there were no differences in miscarriage, live birth, or preterm birth rates, and no complications such as scar pregnancy or placental abnormalities were observed in either group. These findings suggest that hysteroscopic treatment of CSD in symptomatic patients undergoing FET does not increase the risk of pregnancy complications and can lead to comparable clinical pregnancy rates with asymptomatic patients. Further studies with larger sample sizes are needed to confirm these results and evaluate long-term reproductive outcomes following CSD repair.
这项回顾性队列研究旨在比较接受冻融胚胎移植(FET)的剖宫产瘢痕缺损(CSD)患者在接受或未接受宫腔镜修复手术时的临床结局。该研究纳入了82例患者,其中手术组A有48例患者(接受CSD修复),手术组B有34例患者(接受宫腔镜治疗其他子宫病变)。结果显示,与B组相比,A组患者的CSD体积更大且形状不同。然而,两组的临床妊娠率没有显著差异。此外,流产、活产或早产率也没有差异,两组均未观察到瘢痕妊娠或胎盘异常等并发症。这些发现表明,对接受FET的有症状患者进行宫腔镜治疗CSD不会增加妊娠并发症的风险,并且可以导致与无症状患者相当的临床妊娠率。需要更大样本量的进一步研究来证实这些结果,并评估CSD修复后的长期生殖结局。