小鼠淋巴结淋巴细胞亚群在抗原诱导的[14C] - 胸腺嘧啶核苷掺入中的相互作用：T细胞和B细胞在对抗抗原反应中的协同作用。
Interaction of subpopulations of murine lymph node lymphocytes in antigen-induced [14C]-thymidine incorporation: T and B cell synergy in the response to antigen.
作者信息
Brummer E, Bhardwaj N, Lawrence H S
出版信息
Immunology. 1979 Oct;38(2):301-10.
The antigen-induced [14C]-thymidine incorporation of murine lymph node cells (LNC) that were non-adherent (NAD) or adherent (AD) to nylon wool was studied. In contrast to NAD-LNC, AD-LNC responded like unfractionated LNC, and these responses were T lymphocyte dependent. By co-culturing NAD-LNC with subpopulations of AD-LNC the cellular requirements and interactions necessary for maximal incorporation of [14C]-thymidine were determined. A synergistic effect was observed when NAD-LNC and AD-LNC were co-cultured. Synergism was not dependent on T lymphocytes or macrophages in the AD-LNC population but was associated with the B lymphocyte subpopulation. These results indicate that the number of B lymphocytes present in a population of LNC can significantly influence the magnitude of the response to antigen.
研究了对尼龙毛不粘附（NAD）或粘附（AD）的小鼠淋巴结细胞（LNC）的抗原诱导的[14C] - 胸苷掺入情况。与NAD - LNC不同，AD - LNC的反应类似于未分离的LNC，且这些反应依赖于T淋巴细胞。通过将NAD - LNC与AD - LNC亚群共培养，确定了[14C] - 胸苷最大掺入所需的细胞需求和相互作用。当NAD - LNC和AD - LNC共培养时观察到协同效应。协同作用不依赖于AD - LNC群体中的T淋巴细胞或巨噬细胞，而是与B淋巴细胞亚群相关。这些结果表明，LNC群体中存在的B淋巴细胞数量可显著影响对抗原的反应强度。
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