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小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性

T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.

作者信息

Kina T, Nishikawa S, Katsura Y

出版信息

Immunology. 1982 Jul;46(3):575-81.

PMID:6980185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555295/
Abstract

T-cell regulation of pokeweed mitogen (PWM)-induced polyclonal immunoglobulin (Ig) production was studied in mice. Under optimal stimulating conditions, about 1000 Ig-producing cells were generated per 3 x 10(5) spleen cells and macrophages were required to generate Ig-producing cells from B lymphocytes. The response of splenic B cells to PWM was partially dependent upon helper T cells, whereas the response to lymph node B cells was completely dependent upon T cells. Helper activity was attributed not only to Lyt 1+ 2- but also to Lyt 1+ 2+ T cells. Co-operation between T and B cells, in this system, was not restricted by H-2 barrier.

摘要

在小鼠中研究了T细胞对商陆丝裂原（PWM）诱导的多克隆免疫球蛋白（Ig）产生的调节作用。在最佳刺激条件下，每3×10⁵个脾细胞约产生1000个产生Ig的细胞，并且需要巨噬细胞从B淋巴细胞产生产生Ig的细胞。脾B细胞对PWM的反应部分依赖于辅助性T细胞，而对淋巴结B细胞的反应则完全依赖于T细胞。辅助活性不仅归因于Lyt 1⁺2⁻ T细胞，也归因于Lyt 1⁺2⁺ T细胞。在该系统中，T细胞和B细胞之间的合作不受H-2屏障的限制。

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T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性
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T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。II. 抑制性T细胞的诱导机制。
Immunology. 1982 Jul;46(3):583-7.

本文引用的文献

1
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
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Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
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4
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。II. 抑制性T细胞的诱导机制。
Immunology. 1982 Jul;46(3):583-7.
5
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J Immunol Methods. 1974 Aug;5(3):239-47. doi: 10.1016/0022-1759(74)90108-2.
6
Selective triggering of human T and B lymphocytes in vitro by polyclonal mitogens.多克隆有丝分裂原在体外对人T和B淋巴细胞的选择性触发
J Exp Med. 1974 Jul 1;140(1):1-18. doi: 10.1084/jem.140.1.1.
7
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