Suppr超能文献

小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性

T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.

作者信息

Kina T, Nishikawa S, Katsura Y

出版信息

Immunology. 1982 Jul;46(3):575-81.

PMID:6980185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555295/
Abstract

T-cell regulation of pokeweed mitogen (PWM)-induced polyclonal immunoglobulin (Ig) production was studied in mice. Under optimal stimulating conditions, about 1000 Ig-producing cells were generated per 3 x 10(5) spleen cells and macrophages were required to generate Ig-producing cells from B lymphocytes. The response of splenic B cells to PWM was partially dependent upon helper T cells, whereas the response to lymph node B cells was completely dependent upon T cells. Helper activity was attributed not only to Lyt 1+ 2- but also to Lyt 1+ 2+ T cells. Co-operation between T and B cells, in this system, was not restricted by H-2 barrier.

摘要

在小鼠中研究了T细胞对商陆丝裂原（PWM）诱导的多克隆免疫球蛋白（Ig）产生的调节作用。在最佳刺激条件下，每3×10⁵个脾细胞约产生1000个产生Ig的细胞，并且需要巨噬细胞从B淋巴细胞产生产生Ig的细胞。脾B细胞对PWM的反应部分依赖于辅助性T细胞，而对淋巴结B细胞的反应则完全依赖于T细胞。辅助活性不仅归因于Lyt 1⁺2⁻ T细胞，也归因于Lyt 1⁺2⁺ T细胞。在该系统中，T细胞和B细胞之间的合作不受H-2屏障的限制。

相似文献

1
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. I. Characterization of helper T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。I. 辅助性T细胞的特性
Immunology. 1982 Jul;46(3):575-81.
2
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。II. 抑制性T细胞的诱导机制。
Immunology. 1982 Jul;46(3):583-7.
3
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. III. Role of Lyt 1+2- non-helper T cells in the suppression.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。III. Lyt 1+2-非辅助性T细胞在抑制中的作用。
Immunology. 1982 Nov;47(3):525-30.
4
Immunoregulatory functions of cultured human T lymphocytes.培养的人T淋巴细胞的免疫调节功能。
Trans Assoc Am Physicians. 1980;93:251-62.
5
B lymphocyte function in patients with rheumatoid arthritis: impact of regulatory T lymphocytes and macrophages--modulation by antirheumatic drugs.类风湿关节炎患者的B淋巴细胞功能：调节性T淋巴细胞和巨噬细胞的影响——抗风湿药物的调节作用
Dan Med Bull. 1988 Apr;35(2):140-57.
6
The role of interleukin 2 in inducing Ig production in a pokeweed mitogen-stimulated mononuclear cell system.白细胞介素2在商陆丝裂原刺激的单核细胞系统中诱导免疫球蛋白产生的作用。
J Immunol. 1987 Feb 1;138(3):795-801.
7
PPD-induced immunoglobulin production in human peripheral blood lymphocytes. II. Separation of PPD-reactive helper T cells from PWM-reactive helper T cells in polyclonal immunoglobulin production of human peripheral blood lymphocytes.结核菌素纯蛋白衍生物（PPD）诱导人外周血淋巴细胞产生免疫球蛋白。II. 在人外周血淋巴细胞多克隆免疫球蛋白产生过程中，从对美洲商陆有丝分裂原（PWM）反应性辅助性T细胞中分离出对PPD反应性辅助性T细胞。
J Immunol. 1979 Sep;123(3):1106-9.
8
Pokeweed mitogen stimulated immunoglobulin production by peripheral blood lymphocytes in vitro: evidence for disordered immunoregulation in patients with ulcerative colitis and Crohn's disease.美洲商陆促有丝分裂原在体外刺激外周血淋巴细胞产生免疫球蛋白：溃疡性结肠炎和克罗恩病患者免疫调节紊乱的证据。
Clin Exp Immunol. 1983 Dec;54(3):739-46.
9
The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin.一种可溶性人T淋巴细胞衍生因子的产生，该因子在体外免疫球蛋白产生过程中可替代辅助性T淋巴细胞。
Immunology. 1979 Mar;36(3):407-13.
10
Implications for the role of cognate interactions in in vitro human B cell activation by Staphylococcus aureus Cowan I and pokeweed mitogen.同源相互作用在金黄色葡萄球菌考恩I和商陆丝裂原体外激活人B细胞中的作用
J Clin Invest. 1986 Jan;77(1):294-300. doi: 10.1172/JCI112290.

引用本文的文献

1
High frequency of lambda gene activation in bone marrow pre-B cells.骨髓前B细胞中λ基因激活的高频率。
J Exp Med. 1984 Feb 1;159(2):617-22. doi: 10.1084/jem.159.2.617.
2
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. III. Role of Lyt 1+2- non-helper T cells in the suppression.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。III. Lyt 1+2-非辅助性T细胞在抑制中的作用。
Immunology. 1982 Nov;47(3):525-30.
3
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。II. 抑制性T细胞的诱导机制。
Immunology. 1982 Jul;46(3):583-7.

本文引用的文献

1
T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1612-6. doi: 10.1073/pnas.77.3.1612.
2
Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.抗原特异性辅助性T细胞可多克隆地刺激H-2相容和H-2不相容的B细胞母细胞。
J Exp Med. 1980 Jan 1;151(1):194-203. doi: 10.1084/jem.151.1.194.
3
Developmental and communicative interrelations of Ly123 and Ly1 cell sets.Ly123和Ly1细胞集的发育及交流相互关系。
J Exp Med. 1980 Mar 1;151(3):566-72. doi: 10.1084/jem.151.3.566.
4
T-cell regulation of pokeweed-mitogen-induced polyclonal immunoglobulin production in mice. II. Mechanism of the induction of suppressor T cells.小鼠中T细胞对商陆丝裂原诱导的多克隆免疫球蛋白产生的调节。II. 抑制性T细胞的诱导机制。
Immunology. 1982 Jul;46(3):583-7.
5
Separation of mouse spleen cells by passage through columns of sephadex G-10.通过葡聚糖凝胶G - 10柱对小鼠脾细胞进行分离。
J Immunol Methods. 1974 Aug;5(3):239-47. doi: 10.1016/0022-1759(74)90108-2.
6
Selective triggering of human T and B lymphocytes in vitro by polyclonal mitogens.多克隆有丝分裂原在体外对人T和B淋巴细胞的选择性触发
J Exp Med. 1974 Jul 1;140(1):1-18. doi: 10.1084/jem.140.1.1.
7
Immune responses in vitro. I. Culture conditions for antibody synthesis.体外免疫反应。I. 抗体合成的培养条件。
Cell Immunol. 1972 Feb;3(2):264-76. doi: 10.1016/0008-8749(72)90165-7.
8
H-2 dependence of co-operation between T and B cells in vivo.体内T细胞与B细胞合作的H-2依赖性
J Immunol. 1972 Nov;109(5):940-3.
9
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
10
Histocompatibility and T-B cell cooperation in mouse radiation chimeras.小鼠辐射嵌合体中的组织相容性与T细胞和B细胞协作
J Immunol. 1975 Dec;115(6):1607-12.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验