Feng Lin, Zhang Hang, Liu Ting
Department of Hematology, Institute of Hematology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Front Oncol. 2024 Jun 24;14:1383419. doi: 10.3389/fonc.2024.1383419. eCollection 2024.
The gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The protein product, IKAROS, had been proved to regulate lymphopoiesis. Subsequent mouse model studies have further confirmed its regulating role in lymphopoiesis as well as in hematopoiesis; besides, it associates with immune function, certain immune disorders like common variable immunodeficiency and dysgammaglobulinemia have been proved to be associated with germline mutations. Dysfunction of IKAROS also bears paramount significance in leukemic transformation and alterations of gene predicts a poor prognosis in hematological malignancies. As an independent prognostic marker, has been incorporated in the risk stratification of BCP-ALL and stratification-guided therapy has also been generated. In this review, we provide a concise and comprehensive overview on the multifaceted roles of gene.
该基因编码一种转录因子，属于与染色质重塑相关的锌指DNA结合蛋白家族。其蛋白质产物IKAROS已被证明可调节淋巴细胞生成。随后的小鼠模型研究进一步证实了其在淋巴细胞生成以及造血过程中的调节作用；此外，它与免疫功能相关，已证明某些免疫疾病如常见变异免疫缺陷和免疫球蛋白异常血症与种系突变有关。IKAROS功能障碍在白血病转化中也具有至关重要的意义，基因改变预示着血液系统恶性肿瘤的预后不良。作为一个独立的预后标志物，它已被纳入B细胞前体急性淋巴细胞白血病的风险分层，并且也产生了分层指导治疗。在本综述中，我们对该基因的多方面作用提供了简明而全面的概述。
