China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Environ Sci Technol. 2024 Jul 23;58(29):12875-12887. doi: 10.1021/acs.est.3c11095. Epub 2024 Jul 9.
There has been widespread concern about the health hazards of per- and polyfluoroalkyl substances (PFAS), which may be the risk factor for hyperuricemia with evidence still insufficient in the general population in China. Here, we conducted a nationwide study involving 9,580 adults aged 18 years or older from 2017 to 2018, measured serum concentrations of uric acid and PFAS (PFOA, PFOS, 6:2 Cl-PFESA, PFNA, PFHxS) in participants, to assess the associations of individual PFAS with hyperuricemia, and estimated a joint effect of PFAS mixtures. We found positive associations of higher serum PFAS with elevated odds of hyperuricemia in Chinese adults, with the greatest contribution from PFOA (69.37%). The nonmonotonic dose-response (NMDR) relationships were observed for 6:2 Cl-PFESA and PFHxS with hyperuricemia. Participants with less marine fish consumption, overweight, and obesity may be the sensitive groups to the effects of PFAS on hyperuricemia. We highlight the potential health hazards of legacy long-chain PFAS (PFOA) once again because of the higher weights of joint effects. This study also provides more evidence about the NMDR relationships in PFAS with hyperuricemia and emphasizes a theoretical basis for public health planning to reduce the health hazards of PFAS in sensitive groups.
全氟和多氟烷基物质 (PFAS) 的健康危害引起了广泛关注，它们可能是中国一般人群高尿酸血症的危险因素，但目前证据仍不充分。在这里，我们进行了一项全国性研究，纳入了 2017 年至 2018 年间的 9580 名 18 岁或以上的成年人，测量了参与者血清尿酸和 PFAS（PFOA、PFOS、6:2 Cl-PFESA、PFNA、PFHxS）的浓度，评估了个体 PFAS 与高尿酸血症的关系，并估计了 PFAS 混合物的联合效应。我们发现，血清中 PFAS 浓度升高与中国成年人高尿酸血症的患病风险呈正相关，其中 PFOA 的贡献最大（69.37%）。对于 6:2 Cl-PFESA 和 PFHxS 与高尿酸血症之间存在非单调剂量反应（NMDR）关系。低海产品摄入、超重和肥胖的参与者可能是 PFAS 对高尿酸血症影响的敏感人群。我们再次强调长链 PFAS（PFOA）的潜在健康危害，因为联合效应的权重更高。本研究还提供了更多关于 PFAS 与高尿酸血症之间 NMDR 关系的证据，并强调了为减少敏感人群 PFAS 的健康危害而进行公共卫生规划的理论基础。
