来自一个受住宅暴露影响社区的人体血清和尿液样本中的全氟和多氟烷基物质。
Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community.
作者信息
Worley Rachel Rogers, Moore Susan McAfee, Tierney Bruce C, Ye Xiaoyun, Calafat Antonia M, Campbell Sean, Woudneh Million B, Fisher Jeffrey
机构信息
Division of Community Health Investigations, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA.
Division of Community Health Investigations, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA.
出版信息
Environ Int. 2017 Sep;106:135-143. doi: 10.1016/j.envint.2017.06.007. Epub 2017 Jun 20.
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS) are considered chemicals of emerging concern, in part due to their environmental and biological persistence and the potential for widespread human exposure. In 2007, a PFAS manufacturer near Decatur, Alabama notified the United States Environmental Protection Agency (EPA) it had discharged PFAS into a wastewater treatment plant, resulting in environmental contamination and potential exposures to the local community.
OBJECTIVES
To characterize PFAS exposure over time, the Agency for Toxic Substances and Disease Registry (ATSDR) collected blood and urine samples from local residents.
METHODS
Eight PFAS were measured in serum in 2010 (n=153). Eleven PFAS were measured in serum, and five PFAS were measured in urine (n=45) from some of the same residents in 2016. Serum concentrations were compared to nationally representative data and change in serum concentration over time was evaluated. Biological half-lives were estimated for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) using a one-compartment pharmacokinetic model.
RESULTS
In 2010 and 2016, geometric mean PFOA and PFOS serum concentrations were elevated in participants compared to the general U.S.
POPULATION
In 2016, the geometric mean PFHxS serum concentration was elevated compared to the general U.S.
POPULATION
Geometric mean serum concentrations of PFOA, PFOS, and perfluorononanoic acid (PFNA) were significantly (p≤0.0001) lower (49%, 53%, and 58%, respectively) in 2016 compared to 2010. Half-lives for PFOA, PFOS, and PFHxS were estimated to be 3.9, 3.3, and 15.5years, respectively. Concentrations of PFOA in serum and urine were highly correlated (r=0.75) in males.
CONCLUSIONS
Serum concentrations of some PFAS are decreasing in this residentially exposed community, but remain elevated compared to the U.S. general population.
背景
全氟和多氟烷基物质（PFAS）被视为新出现的受关注化学品，部分原因是它们在环境和生物体内具有持久性，且人类有广泛接触的可能性。2007年，阿拉巴马州迪凯特附近的一家PFAS制造商通知美国环境保护局（EPA），其已将PFAS排放到一家污水处理厂，导致环境污染以及当地社区可能受到暴露。
目的
为了描述PFAS随时间的暴露情况，有毒物质和疾病登记署（ATSDR）收集了当地居民的血液和尿液样本。
方法
2010年在血清中检测了8种PFAS（n = 153）。2016年对部分相同居民的血清检测了11种PFAS，对尿液检测了5种PFAS（n = 45）。将血清浓度与全国代表性数据进行比较，并评估血清浓度随时间的变化。使用单室药代动力学模型估计全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和全氟己烷磺酸（PFHxS）的生物半衰期。
结果
2010年和2016年，与美国普通人群相比，参与者血清中PFOA和PFOS的几何平均浓度升高。
人群
2016年，与美国普通人群相比，PFHxS血清几何平均浓度升高。
人群
2016年，PFOA、PFOS和全氟壬酸（PFNA）的血清几何平均浓度与2010年相比显著降低（分别降低49%、53%和58%，p≤0.0001）。PFOA、PFOS和PFHxS的半衰期估计分别为3.9年、3.3年和15.5年。男性血清和尿液中PFOA的浓度高度相关（r = 0.75）。
结论
在这个受居住暴露影响的社区中，一些PFAS的血清浓度正在下降，但与美国普通人群相比仍处于升高水平。
Zotero 插件