Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475004, China.
School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475004, China.
Apoptosis. 2024 Oct;29(9-10):1377-1392. doi: 10.1007/s10495-024-01992-z. Epub 2024 Jul 9.
Ferroptosis is a programmed cell death that relies on iron and lipid peroxidation. It differs from other forms of programmed cell death such as necrosis, apoptosis and autophagy. More and more evidence indicates that ferroptosis participates in many types of diseases, such as neurodegenerative diseases, ischemia-reperfusion injury, cardiovascular diseases and so on. Hence, clarifying the role and mechanism of ferroptosis in diseases is of great significance for further understanding the pathogenesis and treatment of some diseases. Hydrogen sulfide (HS) is a colorless and flammable gas with the smell of rotten eggs. Many years ago, HS was considered as a toxic gas. however, in recent years, increasing evidence indicates that it is the third important gas signaling molecule after nitric oxide and carbon monoxide. HS has various physiological and pathological functions such as antioxidant stress, anti-inflammatory, anti-apoptotic and anti-tumor, and can participate in various diseases. It has been reported that HS regulation of ferroptosis plays an important role in many types of diseases, however, the related mechanisms are not fully clear. In this review, we reviewed the recent literature about the role of HS regulation of ferroptosis in diseases, and analyzed the relevant mechanisms, hoping to provide references for future in-depth researches.
铁死亡是一种依赖于铁和脂质过氧化的程序性细胞死亡。它不同于其他形式的程序性细胞死亡，如坏死、细胞凋亡和自噬。越来越多的证据表明，铁死亡参与多种疾病，如神经退行性疾病、缺血再灌注损伤、心血管疾病等。因此，阐明铁死亡在疾病中的作用和机制对于进一步了解某些疾病的发病机制和治疗方法具有重要意义。硫化氢（HS）是一种无色、易燃的气体，具有臭鸡蛋的气味。多年前，HS 被认为是一种有毒气体。然而，近年来，越来越多的证据表明，它是继一氧化氮和一氧化碳之后的第三种重要的气体信号分子。HS 具有抗氧化应激、抗炎、抗细胞凋亡和抗肿瘤等多种生理和病理功能，并能参与多种疾病。据报道，HS 调节铁死亡在多种疾病中起着重要作用，但其相关机制尚不完全清楚。在这篇综述中，我们回顾了关于 HS 调节铁死亡在疾病中的作用的最新文献，并分析了相关机制，希望为未来的深入研究提供参考。
