Pastina Joseph T, Abel Mark G, Bollinger Lance M, Best Stuart A
Department of Kinesiology & Health Promotion, The University of Kentucky, Lexington, Kentucky, USA.
Cannabis Cannabinoid Res. 2024 Jul 9. doi: 10.1089/can.2024.0012.
The purpose of this pilot study was to investigate cannabidiol (CBD) cream's effects on muscle soreness and performance after exercise. This double-blinded, placebo-controlled experiment included 15 men and 13 women ( = 28; mean ± standard deviation age: 23.29 ± 2.54 years) untrained in lower-body resistance training. Participants were randomized into control (NG, = 9), CBD (CG, = 9), or placebo (PG, = 10) groups. Participants completed a lower-body fatigue protocol (FP) consisting of unilateral maximal concentric and eccentric isokinetic muscle actions of the quadriceps and hamstrings (5 sets, 10 repetitions, both legs). CG and PG participants applied ∼100 mg CBD or placebo cream, respectively, matched for weight and appearance to the quadriceps on three separate days. NG participants engaged in a sitting rest period matched in duration to cream application processes. Questionnaires, pressure-pain threshold (PPT), peak torque test (PTT), and countermovement jump (CMJ) were assessed. Mixed-model analysis of variance was conducted to assess main effects and interactions (group × muscle × time; group × time). There were no significant interactions or main effects for group for PPT, CMJ, or PTT. There were main effects for time ( < 0.05) for all soreness questions, PPT, CMJ, and PTT. There was one significant interaction (group × time; = 0.045) for cream/rest effect questions, in which PG participants perceived the effect of cream to be greater than the effect of rest for NG participants. There were main effects for group ( ≤ 0.031) for all soreness questions, in which PG participants perceived enhanced recovery. The present pilot study did not discover any significant impacts of CBD cream use for muscle recovery. For individuals seeking to attenuate muscle soreness and improve performance, the current dose of this topical CBD product may not be an effective treatment.
这项初步研究的目的是调查大麻二酚（CBD）乳膏对运动后肌肉酸痛和运动表现的影响。这项双盲、安慰剂对照实验纳入了15名男性和13名女性（n = 28；平均±标准差年龄：23.29±2.54岁），他们未接受过下肢抗阻训练。参与者被随机分为对照组（NG，n = 9）、CBD组（CG，n = 9）或安慰剂组（PG，n = 10）。参与者完成了一项下肢疲劳方案（FP），包括股四头肌和腘绳肌的单侧最大向心和离心等速肌肉动作（5组，每组10次重复，双腿）。CG组和PG组参与者分别在三天内将约100毫克CBD或安慰剂乳膏涂抹于股四头肌，乳膏的重量和外观相互匹配。NG组参与者进行与乳膏涂抹过程时长相同的坐姿休息。评估了问卷、压力疼痛阈值（PPT）、峰值扭矩测试（PTT）和反向运动跳跃（CMJ）。进行了混合模型方差分析以评估主要效应和交互作用（组×肌肉×时间；组×时间）。对于PPT、CMJ或PTT，组间没有显著的交互作用或主要效应。对于所有酸痛问题、PPT、CMJ和PTT，时间有主要效应（P < 0.05）。对于乳膏/休息效果问题，有一个显著的交互作用（组×时间；P = 0.045），其中PG组参与者认为乳膏的效果大于NG组参与者休息的效果。对于所有酸痛问题，组间有主要效应（P ≤ 0.031），其中PG组参与者感觉恢复增强。本初步研究未发现使用CBD乳膏对肌肉恢复有任何显著影响。对于寻求减轻肌肉酸痛和改善运动表现的个体，这种局部用CBD产品的当前剂量可能不是一种有效的治疗方法。
