与低甲基化药物诱导相比，初治异基因造血细胞移植治疗骨髓增生异常综合征的疗效更佳。 - Suppr

Superior outcome of upfront allogeneic hematopoietic cell transplantation versus hypomethylating agent induction in myelodysplastic syndrome.

作者信息

Schroeder Jan Christian, Mix Lucas, Faustmann Philipp, Weller Jan Frederic, Fehn Adrian, Phely Laurent, Riedel Andreas, Vogel Wichard, Faul Christoph, Lengerke Claudia, Bethge Wolfgang Andreas

机构信息

Department for Internal Medicine 2, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany.

出版信息

Bone Marrow Transplant. 2024 Sep;59(9):1332-1334. doi: 10.1038/s41409-024-02365-5. Epub 2024 Jul 9.

DOI:10.1038/s41409-024-02365-5

PMID:38982155

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11368806/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d6/11368806/0bc5424eb19b/41409_2024_2365_Fig1_HTML.jpg

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Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial.复发或反应不佳的急性髓系白血病患者的缓解诱导与立即进行异基因造血干细胞移植（ASAP）：一项随机、开放标签、3期、非劣效性试验。

Lancet Haematol. 2024 May;11(5):e324-e335. doi: 10.1016/S2352-3026(24)00065-6. Epub 2024 Apr 4.

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Biol Blood Marrow Transplant. 2019 Aug;25(8):1550-1559. doi: 10.1016/j.bbmt.2019.03.011. Epub 2019 Mar 15.

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel.异基因造血干细胞移植治疗骨髓增生异常综合征和慢性粒-单核细胞白血病：国际专家小组的建议

Blood. 2017 Mar 30;129(13):1753-1762. doi: 10.1182/blood-2016-06-724500. Epub 2017 Jan 17.

Should cytoreductive treatment be performed before transplantation in patients with high-risk myelodysplastic syndrome?对于高危骨髓增生异常综合征患者，是否应在移植前进行减瘤治疗？

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Superior outcome of upfront allogeneic hematopoietic cell transplantation versus hypomethylating agent induction in myelodysplastic syndrome.

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