School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, Hubei, China.
Commun Biol. 2024 Jul 9;7(1):838. doi: 10.1038/s42003-024-06520-y.
Aberrant RNA editing has emerged as a pivotal factor in the pathogenesis of hepatocellular carcinoma (HCC), but the impact of RNA co-editing within HCC remains underexplored. We used a multi-step algorithm to construct an RNA co-editing network in HCC, and found that HCC-related RNA editings are predominantly centralized within the network. Furthermore, five pairs of risk RNA co-editing events were significantly correlated with the overall survival in HCC. Based on presence of risk RNA co-editings resulted in the categorization of HCC patients into high-risk and low-risk groups. Disparities in immune cell infiltrations were observed between the two groups, with the high-risk group exhibiting a greater abundance of exhausted T cells. Additionally, seven genes associated with risk RNA co-editing pairs were identified, whose expression effectively differentiates HCC tumor samples from normal ones. Our research offers an innovative perspective on the etiology and potential therapeutics for HCC.
RNA 编辑异常已成为肝细胞癌 (HCC) 发病机制中的关键因素，但 HCC 内 RNA 共编辑的影响仍未得到充分探索。我们使用多步算法构建了 HCC 的 RNA 共编辑网络，发现 HCC 相关的 RNA 编辑主要集中在网络内。此外，五对与 HCC 总体生存率显著相关的风险 RNA 共编辑事件。基于存在风险 RNA 共编辑，将 HCC 患者分为高危组和低危组。两组之间观察到免疫细胞浸润的差异，高危组衰竭 T 细胞的丰度更高。此外，还鉴定出与风险 RNA 共编辑对相关的七个基因，其表达可有效区分 HCC 肿瘤样本与正常样本。我们的研究为 HCC 的病因学和潜在治疗方法提供了新的视角。
