Mattie H, Meenhorst P L
Infection. 1979;7 Suppl 5:S456-7. doi: 10.1007/BF01659770.
To establish the clinical value of antibiotics, clinical trials are necessary. Both bacteriological and clinical-pharmacological data are helpful when designing a proper clinical trial. The difference between amoxicillin and ampicillin preparations cannot be defined on pharmacokinetic grounds alone. The difference in absorption between ampicillin and either pivampicillin or bacampicillin shows the latter two to be superior.
为确定抗生素的临床价值，进行临床试验很有必要。在设计恰当的临床试验时，细菌学和临床药理学数据均有帮助。仅基于药代动力学依据无法界定阿莫西林和氨苄西林制剂之间的差异。氨苄西林与匹氨西林或巴氨西林在吸收方面的差异表明后两者更具优势。
