Molin L, Bolla K
Surv Immunol Res. 1985;4 Suppl 1:135-8.
The case histories of 2 patients with chronic Trichophyton rubrum infections are presented. Both subjects had previously been treated systemically with griseofulvin, but had to be dropped from therapy due to adverse reactions. Topical treatment alone yielded unsatisfactory results. Thymopentin, 50 mg, administered subcutaneously three times weekly for a period of 6 weeks, induced rapid improvement within 3 weeks and almost complete remission 3 weeks later, although the fungi were still present on the skin. This beneficial effect lasted for up to 7 months after cessation of thymopentin therapy. Reinstitution of treatment produced the same response pattern. The clinical and immunological implications of these findings are briefly discussed; thymopentin is believed to enhance the suggested impaired cellular immunity in patients with chronic T. rubum infections.
本文介绍了2例慢性红色毛癣菌感染患者的病历。两名患者此前均接受过灰黄霉素全身治疗，但因不良反应而不得不停止治疗。仅采用局部治疗效果不佳。胸腺五肽，50毫克，每周皮下注射三次，持续6周，在3周内迅速改善，3周后几乎完全缓解，尽管皮肤真菌仍然存在。这种有益效果在胸腺五肽治疗停止后持续长达7个月。重新开始治疗产生了相同的反应模式。简要讨论了这些发现的临床和免疫学意义；胸腺五肽被认为可增强慢性红色毛癣菌感染患者中推测受损的细胞免疫。
