Ghetti P, Negosanti M, Andriani G C, Beltrandi E, Maldini M
Minerva Ginecol. 1989 Feb;41(2):113-6.
Twelve patients who had been suffering from genital and/or perianal recurrent condyloma acuminatum for a minimum of 5 to a maximum of 24 months, in spite of treatment, were studied from the immunological viewpoint and treated with 50 mg s.c. Thymopentin three times a week for 4 or 6 weeks. Six of the patients were cured at the end of treatment, five after 5 months, and one was not cured. Analysis of the clinico-laboratory data shows a significant agreement between the course of clinical signs and the immunological picture. The various cure stages are probably attributable to the basic immune arrangement which was more impaired in the 5 patients who were cured more slowly and in the non-cured case. In the latter too, however, Thymopentin permitted correcting the balance of the relationship between the various lymphocyte subpopulations.
对12例尽管经过治疗但仍患有生殖器和/或肛周复发性尖锐湿疣至少5个月至最长24个月的患者进行了免疫学研究，并给予皮下注射胸腺五肽50毫克，每周3次，共4或6周。6例患者在治疗结束时治愈，5例在5个月后治愈，1例未治愈。临床实验室数据分析显示临床体征过程与免疫状况之间存在显著一致性。不同的治愈阶段可能归因于基本免疫状态，在治愈较慢的5例患者和未治愈的病例中，免疫状态受损更严重。然而，在后者中，胸腺五肽也能够纠正不同淋巴细胞亚群之间关系的平衡。
