• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

剪切敏感的环状RNA-LONP2通过靶向NRF2/HO1信号通路促进内皮炎症和动脉粥样硬化。

Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling.

作者信息

Wang Ruoyu, Zeng Yue, Chen Ziqi, Ma Dongwei, Zhang Xiaozhe, Wu Guifu, Fan Wendong

机构信息

Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, People's Republic of China.

NHC Key Laboratory of Assisted Circulation and Vascular Diseases (Sun Yat-sen University).

出版信息

JACC Basic Transl Sci. 2024 May 27;9(5):652-670. doi: 10.1016/j.jacbts.2024.02.019. eCollection 2024 May.

DOI:10.1016/j.jacbts.2024.02.019
PMID:38984054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11228119/
Abstract

Hemodynamic shear stress is a frictional force that acts on vascular endothelial cells and is essential for endothelial homeostasis. Physiological laminar shear stress (LSS) suppresses endothelial inflammation and protects arteries from atherosclerosis. Herein, we screened differentially expressed circular RNAs (circRNAs) that were significantly altered in LSS-stimulated endothelial cells and found that circRNA-LONP2 was involved in modulating the flow-dependent inflammatory response. Furthermore, endothelial circRNA-LONP2 overexpression promoted endothelial inflammation and atherosclerosis in vitro and in vivo. Mechanistically, circRNA-LONP2 competitively sponged miR-200a-3p and subsequently promoted Kelch-like ECH-associated protein 1, Yes-associated protein 1, and enhancer of zeste homolog 2 expression, thereby inactivating nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling, promoting oxidative stress and endothelial inflammation, and accelerating atherosclerosis. LSS-induced down-regulation of circRNA-LONP2 suppresses endothelial inflammation, at least in part, by activating the miR-200a-3p-mediated nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway. CircRNA-LONP2 may serve as a new therapeutic target for atherosclerosis.

摘要

血流动力学剪切应力是一种作用于血管内皮细胞的摩擦力，对内皮稳态至关重要。生理性层流剪切应力（LSS）可抑制内皮炎症，并保护动脉免受动脉粥样硬化的影响。在此，我们筛选了在LSS刺激的内皮细胞中显著改变的差异表达环状RNA（circRNA），发现circRNA-LONP2参与调节血流依赖性炎症反应。此外，内皮circRNA-LONP2过表达在体外和体内均促进了内皮炎症和动脉粥样硬化。机制上，circRNA-LONP2竞争性结合miR-200a-3p，随后促进 Kelch样ECH相关蛋白1、Yes相关蛋白1和zeste同源物2增强子的表达，从而使核因子红细胞2相关因子2/血红素加氧酶-1信号失活，促进氧化应激和内皮炎症，并加速动脉粥样硬化。LSS诱导的circRNA-LONP2下调至少部分通过激活miR-200a-3p介导的核因子红细胞2相关因子2/血红素加氧酶-1信号通路来抑制内皮炎症。CircRNA-LONP2可能成为动脉粥样硬化的一个新的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/ae3a808ccc70/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/83e318ac00d6/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/6806562c3bf8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/e18cacea317e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/23d02fc0e3b2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/e11aa07bcbb6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/a4fda0fc6631/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/29e8bc36dcb1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/ae3a808ccc70/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/83e318ac00d6/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/6806562c3bf8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/e18cacea317e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/23d02fc0e3b2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/e11aa07bcbb6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/a4fda0fc6631/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/29e8bc36dcb1/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0af1/11228119/ae3a808ccc70/gr7.jpg

相似文献

1
Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling.剪切敏感的环状RNA-LONP2通过靶向NRF2/HO1信号通路促进内皮炎症和动脉粥样硬化。
JACC Basic Transl Sci. 2024 May 27;9(5):652-670. doi: 10.1016/j.jacbts.2024.02.019. eCollection 2024 May.
2
Stressing the Circle: Circular RNA-LONP2 Role in Atherosclerosis.强调循环：环状RNA-LONP2在动脉粥样硬化中的作用
JACC Basic Transl Sci. 2024 May 27;9(5):671-673. doi: 10.1016/j.jacbts.2024.04.003. eCollection 2024 May.
3
Differentially Expressed Circular Non-coding RNAs in Atherosclerotic Aortic Vessels and Their Potential Functions in Endothelial Injury.动脉粥样硬化主动脉血管中差异表达的环状非编码RNA及其在内皮损伤中的潜在功能
Front Cardiovasc Med. 2021 Jul 7;8:657544. doi: 10.3389/fcvm.2021.657544. eCollection 2021.
4
MicroRNA-200a improves diabetic endothelial dysfunction by targeting KEAP1/NRF2.微小 RNA-200a 通过靶向 KEAP1/NRF2 改善糖尿病血管内皮功能障碍。
J Endocrinol. 2020 Apr;245(1):129-140. doi: 10.1530/JOE-19-0414.
5
miR-200a attenuated oxidative stress, inflammation, and apoptosis in dextran sulfate sodium-induced colitis through activation of Nrf2.miR-200a 通过激活 Nrf2 减轻葡聚糖硫酸钠诱导的结肠炎中的氧化应激、炎症和细胞凋亡。
Front Immunol. 2023 Aug 14;14:1196065. doi: 10.3389/fimmu.2023.1196065. eCollection 2023.
6
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway.冬凌草甲素通过激活核因子红细胞 2 相关因子 2 通路减轻低切应力诱导的内皮细胞功能障碍和氧化应激。
BMC Complement Med Ther. 2022 Jul 7;22(1):180. doi: 10.1186/s12906-022-03658-2.
7
Shear-Sensitive lncRNA AF131217.1 Inhibits Inflammation in HUVECs via Regulation of KLF4.剪切敏感 lncRNA AF131217.1 通过调节 KLF4 抑制 HUVECs 中的炎症反应。
Hypertension. 2019 May;73(5):e25-e34. doi: 10.1161/HYPERTENSIONAHA.118.12476.
8
RHOJ as a novel mechanosensitive modulator of endothelial inflammation.RHOJ 作为一种新型的血管内皮炎症的机械敏感性调节剂。
Biochem Biophys Res Commun. 2023 Aug 30;670:36-46. doi: 10.1016/j.bbrc.2023.05.099. Epub 2023 May 26.
9
Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis.miR-200a的过表达通过调节kelch样ECH相关蛋白1-核因子红细胞2相关因子2信号轴保护心肌细胞免受缺氧诱导的细胞凋亡。
Int J Mol Med. 2016 Oct;38(4):1303-11. doi: 10.3892/ijmm.2016.2719. Epub 2016 Aug 26.
10
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.骨肉瘤中环状RNA的基因芯片表达谱及功能分析
Cell Physiol Biochem. 2017;43(3):969-985. doi: 10.1159/000481650. Epub 2017 Sep 29.

引用本文的文献

1
The Dark Side of Vascular Aging: Noncoding Ribonucleic Acids in Heart Failure with Preserved Ejection Fraction.血管衰老的阴暗面：射血分数保留的心力衰竭中的非编码核糖核酸
Cells. 2025 Aug 16;14(16):1269. doi: 10.3390/cells14161269.
2
Circular RNA role in Atherosclerosis Development and Progression.环状RNA在动脉粥样硬化发生发展中的作用
Curr Atheroscler Rep. 2025 Jun 3;27(1):60. doi: 10.1007/s11883-025-01306-x.
3
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases.

本文引用的文献

1
TMEM215 Prevents Endothelial Cell Apoptosis in Vessel Regression by Blunting BIK-Regulated ER-to-Mitochondrial Ca Influx.跨膜蛋白215通过减弱BIK调节的内质网到线粒体的钙内流来防止血管消退过程中的内皮细胞凋亡。
Circ Res. 2023 Oct 13;133(9):739-757. doi: 10.1161/CIRCRESAHA.123.322686. Epub 2023 Sep 26.
2
Flow-induced reprogramming of endothelial cells in atherosclerosis.血流诱导的动脉粥样硬化中内皮细胞重编程
Nat Rev Cardiol. 2023 Nov;20(11):738-753. doi: 10.1038/s41569-023-00883-1. Epub 2023 May 24.
3
Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1.
针对心血管疾病中内皮功能障碍的机制性见解和新兴治疗策略。
Arch Pharm Res. 2025 Apr;48(4):305-332. doi: 10.1007/s12272-025-01542-4. Epub 2025 Apr 29.
hsa_circ_0000280 通过 ELAVL1 调控血管平滑肌细胞功能和减轻内膜增生的作用。
Cell Mol Life Sci. 2022 Dec 7;80(1):3. doi: 10.1007/s00018-022-04602-w.
4
Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells.Sox13是一种新型的血流敏感转录因子，它通过抑制内皮细胞中的趋化因子表达来预防炎症。
Front Cardiovasc Med. 2022 Sep 30;9:979745. doi: 10.3389/fcvm.2022.979745. eCollection 2022.
5
CircRNAs: Key molecules in the prevention and treatment of ischemic stroke.环状 RNA：预防和治疗缺血性脑卒中的关键分子。
Biomed Pharmacother. 2022 Dec;156:113845. doi: 10.1016/j.biopha.2022.113845. Epub 2022 Oct 13.
6
circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p.circ_0086296 通过海绵吸附 miR-576-3p 诱导 IFIT1/STAT1 反馈环导致动脉粥样硬化病变。
Cell Mol Biol Lett. 2022 Sep 23;27(1):80. doi: 10.1186/s11658-022-00372-2.
7
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis.靶向 VCAM-1 结合肽的载 NLRP3siRNA 阳离子脂质体调节 LDL 转胞吞作用作为实验性动脉粥样硬化的新疗法。
Metabolism. 2022 Oct;135:155274. doi: 10.1016/j.metabol.2022.155274. Epub 2022 Jul 30.
8
CircLONP2 Accelerates Esophageal Squamous Cell Carcinoma Progression Direct MiR-27b-3p-ZEB1 Axis.环状LONP2通过直接调控miR-27b-3p-ZEB1轴加速食管鳞状细胞癌进展。
Front Oncol. 2022 Jul 5;12:822839. doi: 10.3389/fonc.2022.822839. eCollection 2022.
9
Laminar shear stress alleviates monocyte adhesion and atherosclerosis development via miR-29b-3p/CX3CL1 axis regulation.层流切应力通过 miR-29b-3p/CX3CL1 轴调节减轻单核细胞黏附和动脉粥样硬化发展。
J Cell Sci. 2022 Jul 15;135(14). doi: 10.1242/jcs.259696. Epub 2022 Jul 22.
10
CircRNA-miRNA interactions in atherogenesis.动脉粥样硬化发生过程中的环状RNA- microRNA相互作用
Mol Cell Biochem. 2022 Dec;477(12):2703-2733. doi: 10.1007/s11010-022-04455-8. Epub 2022 May 23.