Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410078, China.
Biomed Pharmacother. 2022 Dec;156:113845. doi: 10.1016/j.biopha.2022.113845. Epub 2022 Oct 13.
Ischemic stroke is a prevalent disease that seriously threatens human health. It is characterized by high morbidity, mortality, disability, and recurrence rates, causing a significant economic burden on individuals and society. Circular RNA, a novel non-coding RNA, not only serves as the sponge for microRNAs and proteins but also promotes transcription of their parental genes and translates into peptides. In recent years, circRNAs have emerged as key regulators in ischemic stroke. This article aims to provide new ideas about the pathogenesis and progression of ischemic stroke by reviewing the roles of circRNAs in cerebral ischemic injury and summarizing the association between circRNAs and risk factors for ischemic stroke.
缺血性脑卒中是一种常见疾病，严重威胁人类健康。其具有发病率、死亡率、致残率和复发率高的特点，给个人和社会带来了巨大的经济负担。环状 RNA 是一种新型的非编码 RNA，不仅可以作为 microRNAs 和蛋白质的海绵，还可以促进其亲本基因的转录并翻译成肽。近年来，circRNAs 已成为缺血性脑卒中的关键调节因子。本文通过综述 circRNAs 在脑缺血损伤中的作用，总结 circRNAs 与缺血性脑卒中危险因素的关系，为缺血性脑卒中的发病机制和进展提供新的思路。
