Bahar M, Rosen M, Vickers M D
Anaesthesia. 1985 Jun;40(6):529-32.
In a double-blind clinical trial of 48 patients, nalbuphine, morphine, and pethidine were compared by on-demand intravenous analgesia during the first 24 hours after cholecystectomy. Overall pain relief (visual analogue score) was recorded by the patients as 50 (SEM 4) for nalbuphine, 44 (SEM 4) for morphine and 53 (SEM 5) for pethidine. These scores were not significantly different. The mean demand for each drug over the 24-hour period was 70 (SEM 12) mg for nalbuphine, 46 (SEM 6) mg for morphine and 614 (SEM 49) mg for pethidine. Pain on movement, either during deep breathing or turning, was found to be less well controlled after nalbuphine (70, SEM 2), and pethidine (67 SEM 7) than after morphine (52, SEM 5; p less than 0.01). The incidence of side effects was similar with each drug. Nalbuphine is a useful postoperative analgesic, as effective as pethidine. Nalbuphine 15 mg is apparently equipotent with morphine 10 mg or pethidine 120 mg by this mode of administration.
在一项针对48名患者的双盲临床试验中，对纳布啡、吗啡和哌替啶在胆囊切除术后的最初24小时内按需静脉镇痛效果进行了比较。患者记录的总体疼痛缓解情况（视觉模拟评分）为：纳布啡50（标准误4），吗啡44（标准误4），哌替啶53（标准误5）。这些评分无显著差异。24小时内每种药物的平均需求量为：纳布啡70（标准误12）mg，吗啡46（标准误6）mg，哌替啶614（标准误49）mg。结果发现，与吗啡（52，标准误5；P<0.01）相比，纳布啡（70，标准误2）和哌替啶（67，标准误7）在深呼吸或翻身时的运动痛控制效果较差。每种药物的副作用发生率相似。纳布啡是一种有用的术后镇痛药，与哌替啶效果相当。通过这种给药方式，15mg纳布啡显然与10mg吗啡或120mg哌替啶等效。
