Nagaraj Siranjeevi, Quintanilla-Sánchez Carolina, Ando Kunie, Lopez-Gutierrez Lidia, Doeraene Emilie, Kosa Andreea-Claudia, Aydin Emmanuel, Brion Jean-Pierre, Leroy Karelle
Alzheimer and Other Tauopathies Research Group, Faculty of Medicine, ULB Center for Diabetes Research, ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
Front Mol Neurosci. 2024 Jun 25;17:1423340. doi: 10.3389/fnmol.2024.1423340. eCollection 2024.
Alzheimer's disease (AD) affects the elderly population by causing memory impairments, cognitive and behavioral abnormalities. Currently, no curative treatments exist, emphasizing the need to explore therapeutic options that modify the progression of the disease. MicroRNAs (miRNAs), as non-coding RNAs, demonstrate multifaceted targeting potential and are known to be dysregulated in AD pathology. This mini review focuses on two promising miRNAs, hsa-miR-132 and hsa-miR-129, which consistently exhibit differential regulation in AD. By employing computational predictions and referencing published RNA sequencing dataset, we elucidate the intricate miRNA-mRNA target relationships associated with hsa-miR-132 and hsa-miR-129. Our review consistently identifies the downregulation of hsa-miR-132 and hsa-miR-129 in AD brains as a non-coding RNA molecular signature across studies conducted over the past 15 years in AD research.
阿尔茨海默病（AD）通过导致记忆障碍、认知和行为异常影响老年人群。目前，尚无治愈性治疗方法，这凸显了探索改变疾病进展的治疗方案的必要性。微小RNA（miRNA）作为非编码RNA，具有多方面的靶向潜力，并且已知在AD病理中表达失调。本综述聚焦于两种有前景的miRNA，即hsa-miR-132和hsa-miR-129，它们在AD中始终表现出差异调节。通过使用计算预测并参考已发表的RNA测序数据集，我们阐明了与hsa-miR-132和hsa-miR-129相关的复杂miRNA-mRNA靶标关系。我们的综述一致确定，在过去15年AD研究中开展的各项研究里，AD大脑中hsa-miR-132和hsa-miR-129的下调作为一种非编码RNA分子特征。
