Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China.
Physiology (Bethesda). 2024 Sep 1;39(5):0. doi: 10.1152/physiol.00028.2023.
Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation and stability of atherosclerotic plaques. This review discusses the contribution of the ECM microenvironment in vascular homeostasis and remodeling in atherosclerosis, highlighting Cartilage oligomeric matrix protein (COMP) and its degrading enzyme ADAMTS7 as examples, and proposes potential avenues for future research aimed at identifying novel therapeutic targets for atherosclerosis based on the ECM microenvironment.
血管细胞外基质（ECM）成分、相互作用和机械性能的改变会影响动脉粥样硬化斑块的形成和稳定性。本综述讨论了 ECM 微环境在血管稳态和动脉粥样硬化重塑中的贡献，以软骨寡聚基质蛋白（COMP）及其降解酶 ADAMTS7 为例，并提出了基于 ECM 微环境的动脉粥样硬化潜在的未来研究途径，以确定新的治疗靶点。
