• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Glutamine-glutamate imbalance in the pathogenesis of cardiovascular disease.

作者信息

Liu Ziyang, Ajam Ali, Huang Jun, Yeh Yu-Sheng, Razani Babak

机构信息

Department of Medicine and Vascular Medicine Institute, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA.

Pittsburgh VA Medical Center, Pittsburgh, PA, USA.

出版信息

Nat Cardiovasc Res. 2024 Dec;3(12):1377-1379. doi: 10.1038/s44161-024-00575-0.

DOI:10.1038/s44161-024-00575-0
PMID:39562783
Abstract
摘要

相似文献

1
Glutamine-glutamate imbalance in the pathogenesis of cardiovascular disease.谷氨酰胺-谷氨酸失衡在心血管疾病发病机制中的作用
Nat Cardiovasc Res. 2024 Dec;3(12):1377-1379. doi: 10.1038/s44161-024-00575-0.
2
High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: Case-cohort study within the PREDIMED trial.高血浆谷氨酸水平和低谷氨酰胺/谷氨酸比值与 2 型糖尿病相关：PREDIMED 试验中的病例-队列研究。
Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1040-1049. doi: 10.1016/j.numecd.2019.06.005. Epub 2019 Jun 20.
3
Glutamine-glutamate centered metabolism as the potential therapeutic target against Japanese encephalitis virus-induced encephalitis.以谷氨酰胺-谷氨酸为中心的代谢作为抗日本脑炎病毒所致脑炎的潜在治疗靶点。
Cell Biosci. 2025 Jan 22;15(1):6. doi: 10.1186/s13578-024-01340-3.
4
Dietary Glutamine and Glutamate in Relation to Cardiovascular Disease Incidence and Mortality in the United States Men and Women with Diabetes Mellitus.美国糖尿病男性和女性患者中膳食谷氨酰胺和谷氨酸与心血管疾病发病率和死亡率的关系。
J Nutr. 2023 Nov;153(11):3247-3258. doi: 10.1016/j.tjnut.2023.08.031. Epub 2023 Sep 3.
5
Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome.线粒体脑肌病伴高乳酸血症和卒中样发作（MELAS）综合征患者脑脊液中谷氨酸升高和谷氨酰胺降低。
J Neurol. 2022 Jun;269(6):3238-3248. doi: 10.1007/s00415-021-10942-7. Epub 2022 Jan 28.
6
Dietary glutamine, glutamate and mortality: two large prospective studies in US men and women.饮食谷氨酰胺、谷氨酸与死亡率：美国男女的两项大型前瞻性研究。
Int J Epidemiol. 2018 Feb 1;47(1):311-320. doi: 10.1093/ije/dyx234.
7
Loss of hepatic manganese transporter ZIP8 disrupts serum transferrin glycosylation and the glutamate-glutamine cycle.肝脏锰转运蛋白 ZIP8 的缺失破坏了血清转铁蛋白的糖基化和谷氨酸-谷氨酰胺循环。
J Trace Elem Med Biol. 2023 Jul;78:127184. doi: 10.1016/j.jtemb.2023.127184. Epub 2023 Apr 27.
8
Elevated Glutamate and Glutamine Levels in the Cerebrospinal Fluid of Patients With Probable Alzheimer's Disease and Depression.可能患有阿尔茨海默病和抑郁症患者脑脊液中谷氨酸和谷氨酰胺水平升高。
Front Psychiatry. 2018 Nov 6;9:561. doi: 10.3389/fpsyt.2018.00561. eCollection 2018.
9
Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.在 PREDIMED（地中海饮食预防）试验中，谷氨酸代谢物与心血管事件的发生有关。
J Am Heart Assoc. 2016 Sep 15;5(9):e003755. doi: 10.1161/JAHA.116.003755.
10
Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation.谷氨酸转运和谷氨酸-谷氨酰胺循环受损：亨廷顿突变的下游效应。
Brain. 2002 Aug;125(Pt 8):1908-22. doi: 10.1093/brain/awf180.

引用本文的文献

1
Relationship between amino acid metabolism and inflammation in coronary heart disease (Review).冠心病中氨基酸代谢与炎症的关系（综述）
Int J Mol Med. 2025 Aug;56(2). doi: 10.3892/ijmm.2025.5561. Epub 2025 Jun 6.

本文引用的文献

1
GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls.GLS2通过重塑动脉壁将谷氨酰胺代谢与动脉粥样硬化联系起来。
Nat Cardiovasc Res. 2024 Dec;3(12):1454-1467. doi: 10.1038/s44161-024-00566-1. Epub 2024 Nov 19.
2
ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis.血管内稳态中的 ECM 微环境：动脉粥样硬化的新靶点。
Physiology (Bethesda). 2024 Sep 1;39(5):0. doi: 10.1152/physiol.00028.2023.
3
Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation.
谷氨酰胺通过调节血管平滑肌细胞凋亡和 M1 巨噬细胞活化来预防小鼠腹主动脉瘤。
Int J Med Sci. 2024 May 19;21(8):1414-1427. doi: 10.7150/ijms.96395. eCollection 2024.
4
Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness.饮食摄入和谷氨酰胺-丝氨酸代谢控制病理性血管僵硬。
Cell Metab. 2024 Jun 4;36(6):1335-1350.e8. doi: 10.1016/j.cmet.2024.04.010. Epub 2024 May 2.
5
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk.鉴定一种亮氨酸介导的控制巨噬细胞 mTOR 信号和心血管风险的阈值效应。
Nat Metab. 2024 Feb;6(2):359-377. doi: 10.1038/s42255-024-00984-2. Epub 2024 Feb 19.
6
Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis.人动脉粥样硬化斑块肌成纤维细胞的研究
J Am Heart Assoc. 2023 Nov 7;12(21):e030243. doi: 10.1161/JAHA.123.030243. Epub 2023 Oct 27.
7
Dietary Glutamine and Glutamate in Relation to Cardiovascular Disease Incidence and Mortality in the United States Men and Women with Diabetes Mellitus.美国糖尿病男性和女性患者中膳食谷氨酰胺和谷氨酸与心血管疾病发病率和死亡率的关系。
J Nutr. 2023 Nov;153(11):3247-3258. doi: 10.1016/j.tjnut.2023.08.031. Epub 2023 Sep 3.
8
Serum glutamate and glutamine-to-glutamate ratio are associated with coronary angiography defined coronary artery disease.血清谷氨酸和谷氨酰胺/谷氨酸比值与冠状动脉造影定义的冠心病有关。
Nutr Metab Cardiovasc Dis. 2022 Jan;32(1):186-194. doi: 10.1016/j.numecd.2021.09.021. Epub 2021 Sep 29.
9
Vascular smooth muscle cells in atherosclerosis.动脉粥样硬化中的血管平滑肌细胞。
Nat Rev Cardiol. 2019 Dec;16(12):727-744. doi: 10.1038/s41569-019-0227-9. Epub 2019 Jun 26.
10
Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation.血管平滑肌细胞表型转换和钙化在主动脉瘤形成中的作用。
Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1351-1368. doi: 10.1161/ATVBAHA.119.312787. Epub 2019 May 30.