Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, P. R. China.
Zhejiang Sci-Tech University Shengzhou Innovation Research Institute, Shengzhou 312400, P. R. China.
Chem Commun (Camb). 2024 Jul 25;60(61):7942-7945. doi: 10.1039/d4cc02739f.
We present a method for site-selective diversification of peptides Pd-catalyzed β-C(sp)-H olefination/cyclization. In this protocol, the native methionine residue acts as a directing group, enabling site-specific olefination/cyclization of peptides. This chemistry demonstrates broad substrate scope, offering a versatile tool for peptide ligation.
我们提出了一种通过 Pd 催化的 β-C(sp)-H 烯丙基化/环化实现肽的位点选择性多样化的方法。在这个方案中，天然蛋氨酸残基作为导向基团，实现了肽的位点特异性烯丙基化/环化。这种化学具有广泛的底物范围，为肽键合提供了一种通用的工具。
