Department of Anesthesiology and Reanimation, Ankara Etlik City Hospital, Ankara, Türkiye.
Department of Anesthesiology and Algology, Gazi University Faculty of Medicine, Ankara, Türkiye.
Agri. 2024 Jul;36(3):137-145. doi: 10.14744/agri.2023.90688.
Paracetamol is one of the most widely used analgesics and antipyretics in the world. It is the most commonly used analgesic and antipyretic agent in pregnancy. Paracetamol is known to have toxic effects on the liver, lung, and kidney. In this study, we investigated the effects of long-term chronic paracetamol exposure on the lung, liver, and kidney in newborn rats at different trimesters of pregnancy.
In our study, we formed control (group C), first trimester (group A), and third trimester (group B) groups. Group A had the first seven days of pregnancy and group B had days 15-21. Paracetamol was given orally during the specified periods. On the third postnatal day, pups were euthanized by applying 50 mg/kg ketamine intraperitoneally, and then lung, liver, and kidney tissues were kept under appropriate conditions for examination. A total of 70 pups underwent histopathological examination.
The lung revealed congestion (p<0.0001), and erythrocytes (p<0.0001), the liver revealed significant histopathological findings in terms of the presence of inflammation (p<0.0001), vacuolar degeneration (p<0.0001), and sinusoidal dilatation in groups A and B compared to the control group under light microscopy. MDA and free radical metabolism enzyme activities, CAT, GSH, and SOD were evaluated. While there were no significant differences between the groups in lung and kidney tissues, oxidant parameters were significant in liver tissues.
Our data point out that subacute doses of paracetamol used chronically in different trimesters caused damage to the lung, liver, and kidney tissues of pups.
对乙酰氨基酚是世界上使用最广泛的一种镇痛药和解热药。它是妊娠期间最常用的镇痛药和解热药。已知对乙酰氨基酚对肝脏、肺和肾脏有毒性作用。在这项研究中，我们研究了长期慢性服用对乙酰氨基酚对妊娠不同阶段新生大鼠肺、肝和肾的影响。
在我们的研究中，我们形成了对照组（C 组）、第一孕期组（A 组）和第三孕期组（B 组）。A 组为妊娠的头 7 天，B 组为妊娠的第 15-21 天。在指定期间经口给予对乙酰氨基酚。在出生后的第 3 天，通过腹腔内给予 50mg/kg 的氯胺酮处死幼仔，然后将肺、肝和肾组织保存在适当的条件下进行检查。共有 70 只幼仔接受了组织病理学检查。
肺组织显示充血（p<0.0001）和红细胞（p<0.0001），与对照组相比，A 组和 B 组的肝脏在光镜下观察到明显的炎症（p<0.0001）、空泡变性（p<0.0001）和窦状扩张的组织病理学发现。评估 MDA 和自由基代谢酶活性、CAT、GSH 和 SOD。虽然肺和肾脏组织中各组之间没有显著差异，但肝脏组织中的氧化参数有显著差异。
我们的数据指出，在不同孕期慢性使用亚急性剂量的对乙酰氨基酚会导致幼仔的肺、肝和肾组织损伤。
