Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.
Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, 7 Weiwu Street, Zhengzhou, 450000, China.
Sleep Breath. 2024 Oct;28(5):2147-2153. doi: 10.1007/s11325-024-03100-6. Epub 2024 Jul 10.
Numerous risk factors in paediatric narcolepsy may predispose them to obstructive sleep apnea (OSA). The concurrent presence of OSA in these patients might lead to underdiagnosing narcolepsy. This research investigates the prevalence and potential causality between OSA and paediatric narcolepsy.
A case-control study coupled with a two-sample Mendelian randomization (MR) analysis was employed to explore the prevalence and causal link between paediatric narcolepsy and OSA risk.
The case-control study revealed that paediatric narcolepsy patients are at an increased risk of OSA, with an Odds ratio (OR) of 4.87 (95% CI: 2.20-10.71; P < 0.001). The inverse-variance weighted (IVW) model further suggests a potential causal link between narcolepsy and OSA (IVW OR: 4.671, 95% CI: 1.925-11.290; P < 0.001). Additionally, sensitivity analysis confirmed these findings' reliability.
The findings highlight an elevated prevalence and genetic susceptibility to OSA among paediatric narcolepsy patients, underscoring the necessity for clinical screening of OSA. Continued research is essential to clarify the pathogenic mechanisms and develop potential treatments.
许多小儿嗜睡症的风险因素可能使他们易患阻塞性睡眠呼吸暂停（OSA）。这些患者同时存在 OSA 可能导致嗜睡症漏诊。本研究调查 OSA 与小儿嗜睡症之间的患病率和潜在因果关系。
采用病例对照研究结合两样本孟德尔随机化（MR）分析来探讨小儿嗜睡症和 OSA 风险之间的患病率和因果关系。
病例对照研究显示，小儿嗜睡症患者患 OSA 的风险增加，优势比（OR）为 4.87（95%CI：2.20-10.71；P<0.001）。逆方差加权（IVW）模型进一步提示嗜睡症与 OSA 之间存在潜在的因果关系（IVW OR：4.671，95%CI：1.925-11.290；P<0.001）。此外，敏感性分析证实了这些发现的可靠性。
这些发现强调了小儿嗜睡症患者中 OSA 的患病率升高和遗传易感性，突出了对 OSA 进行临床筛查的必要性。需要进一步研究来阐明发病机制并开发潜在的治疗方法。
