Chen Jing, Shan Rui, Wang Yang, Zhang Xiao-Rui, Xiao Wu-Cai, Liu Zheng
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Eur Child Adolesc Psychiatry. 2025 Feb;34(2):729-738. doi: 10.1007/s00787-024-02518-3. Epub 2024 Jul 10.
We assess the associations between personality traits and co-occurrence of depressive symptoms and high BMI from adolescence to early adulthood. We employed a nationally representative cohort in China from 2010 to 2020 year. We included adolescents aged 10-19 years without depressive symptoms and unhealthy weight status (obesity, overweight, or thinness) at baseline and excluded those without any measurement of depressive symptoms or BMI at follow-ups. We assessed baseline personality traits in 7 dimensions of conscientiousness, openness, neuroticism, agreeableness, extraversion, self-esteem, and responsibility. We also assessed the combined effects of these 7 dimensions of personality traits by generating individual-level personality trait risk scores based on the weighted sum of all these 7 dimensions of personality traits. We measured the co-occurrence of depressive symptoms and high BMI using both a single measurement of depressive symptoms and BMI at the last follow-up and repeated measurements of them over 10 years. We used the multinomial logistic regression models to examine the exposure-outcome associations. At baseline, we included 1778 individuals (mean age: 14.4 year; female: 853 (48.0%)). At follow-ups, we observed increased risk of co-occurrence of depressive symptoms and high BMI per 1-SD increase in neuroticism score (1.95-2.38 odds ratio) or 1-SD decrease in self-esteem and conscientiousness (0.63-0.80 odds ratio; all P values < 0.05); we observed no evidence of associations between openness, agreeableness, extraversion, or responsibility and the risk of co-occurrence of depressive symptoms and high BMI (all P values > 0.05). For the combined effects of the 7 dimensions of personality traits, we found an elevated risk of co-occurrence of depressive symptoms and high BMI per 1-SD increase in the personality trait risk scores (OR (95% CI), single measurement at the last follow-up: 2.01, 1.66 to 2.43; trajectory classification using the repeated measurements 2.30, 1.55 to 3.42; average level using the repeated measurements: 2.27, 1.93 to 2.67). In this national cohort in China, personality traits were found to be associated with the co-occurrence of depressive symptoms and high BMI from adolescence to early adulthood. These findings highlight the importance of stratifying individuals based on their personality traits and providing targeted interventions for those at risk of comorbid depression and obesity.
我们评估了从青春期到成年早期人格特质与抑郁症状和高体重指数（BMI）共现之间的关联。我们采用了2010年至2020年在中国具有全国代表性的队列。我们纳入了基线时年龄在10 - 19岁、无抑郁症状且体重状况健康（非肥胖、非超重、非消瘦）的青少年，并排除了随访时未进行任何抑郁症状或BMI测量的个体。我们从尽责性、开放性、神经质、宜人性、外向性、自尊和责任感这7个维度评估了基线人格特质。我们还通过基于这7个人格特质维度的加权总和生成个体水平的人格特质风险评分，来评估这7个人格特质维度的综合影响。我们使用最后一次随访时抑郁症状和BMI的单次测量以及10年间的重复测量来衡量抑郁症状和高BMI的共现情况。我们使用多项逻辑回归模型来检验暴露 - 结果关联。在基线时，我们纳入了1778名个体（平均年龄：14.4岁；女性：853名（48.0%））。在随访中，我们观察到神经质得分每增加1个标准差（优势比为1.95 - 2.38）或自尊和尽责性得分每降低1个标准差（优势比为0.63 - 0.80；所有P值<0.05），抑郁症状和高BMI共现的风险增加；我们未观察到开放性、宜人性、外向性或责任感与抑郁症状和高BMI共现风险之间存在关联的证据（所有P值>0.05）。对于7个人格特质维度的综合影响，我们发现人格特质风险评分每增加1个标准差，抑郁症状和高BMI共现的风险升高（优势比（95%置信区间），最后一次随访时的单次测量：2.01，1.66至2.43；使用重复测量的轨迹分类：2.30，1.55至3.42；使用重复测量的平均水平：2.27，1.93至2.67）。在中国的这个全国性队列中，发现人格特质与从青春期到成年早期抑郁症状和高BMI的共现有关。这些发现凸显了根据人格特质对个体进行分层，并为有合并抑郁症和肥胖风险的人群提供针对性干预的重要性。
