Yang Ping, Xie Peng, Lin Feng, Wang Tian, Zhang Lian, Yan Fei
Department of Oncology, The Eighth People's Hospital of Shanghai, Shanghai, 200233, China.
Department of Orthopedics, The Third Affliated Hospital The Affliated Luohu Hospital of Shenzhen University, Shenzhen, 518000, China.
J Fluoresc. 2024 Jul 10. doi: 10.1007/s10895-024-03832-4.
This study focuses on the design and synthesis of two novel coordination polymers (CPs), named 1 and 2, with excellent fluorescent properties. Their structures were characterized by X-ray single-crystal diffraction, revealing that both materials exhibit promising fluorescence performance, indicating their potential as fluorescent detection tools. Additionally, 1 was chosen to be combined with chitosan (CS), resulting in the successful fabrication of a biodegradable and non-toxic efficient drug carrier, termed CS-1@Cisplatin. This carrier possesses a large surface area and good solubility, enabling sustained drug release to target cells. Given that CXC motif chemokine receptor type 4 (CXCR4) is a key marker gene highly expressed in Rhabdomyosarcoma (RMS) cells and tissues, RMS was chosen as the biological model for testing. The results demonstrated that CS-1@Cisplatin effectively inhibited the invasiveness of RMS cells by significantly suppressing CXCR4 expression. Therefore, the system shows great potential for applications in RMS treatment, biometrics, and drug delivery, particularly in its unique advantage of targeting RMS by inhibiting the key marker gene CXCR4.
本研究聚焦于两种具有优异荧光性能的新型配位聚合物（CPs）的设计与合成，分别命名为1和2。通过X射线单晶衍射对它们的结构进行了表征，结果表明这两种材料均展现出良好的荧光性能，显示出其作为荧光检测工具的潜力。此外，选择1与壳聚糖（CS）相结合，成功制备了一种可生物降解且无毒的高效药物载体，称为CS-1@顺铂。该载体具有较大的表面积和良好的溶解性，能够实现药物向靶细胞的持续释放。鉴于CXC基序趋化因子受体4（CXCR4）是在横纹肌肉瘤（RMS）细胞和组织中高度表达的关键标记基因，因此选择RMS作为生物学模型进行测试。结果表明，CS-1@顺铂通过显著抑制CXCR4的表达，有效抑制了RMS细胞的侵袭性。因此，该系统在RMS治疗、生物识别和药物递送方面具有巨大的应用潜力，尤其是其通过抑制关键标记基因CXCR4靶向RMS的独特优势。
