Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America.
Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States of America.
PLoS One. 2024 Jul 10;19(7):e0305617. doi: 10.1371/journal.pone.0305617. eCollection 2024.
The aim of this systematic review article is to evaluate the relationship between diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal models. The review focused on studies assessing SNHL in diabetic animal models, elucidating the mechanisms of DM-associated SNHL, and exploring the response of diabetic animal models to noise overexposure. We also discussed studies investigating the efficacy of potential therapeutic strategies for amelioration of DM-associated SNHL in the animal models.
A protocol of this systematic review was designed a priori and was registered in the PROSPERO database (registration number: CRD42023439961). We conducted a comprehensive search on PubMed, Science Direct, Web of Science, Scopus, and EMBASE databases. A minimum of three reviewers independently screened, selected, and extracted data. The risk of bias assessment of eligible studies was conducted using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool.
Following the screening of 238 studies, twelve original articles were included in this systematic review. The studies revealed that hyperglycemia significantly affects auditory function, with various pathological mechanisms contributing to DM-induced hearing impairment, including cochlear synaptopathy, microangiopathy, neuropathy, oxidative stress, mitochondrial abnormalities, and apoptosis-mediated cell death. Emerging interventions, such as Asiaticoside, Trigonelline, Chlorogenic acid, and Huotanquyu granules, demonstrated efficacy in providing otoprotection for preserving cochlear hair cells and hearing function.
Our systematic review delves into the intricate relationship between DM and hearing impairment in animal models. Future research should focus on targeted therapies to enhance cochlear mitochondrial function, alleviate oxidative stress, and regulate apoptosis. The association between SNHL and social isolation as well as cognitive decline underscores the necessity for innovative therapeutic modalities addressing yet undiscovered mechanisms. Translating findings from animal models to human studies will validate these findings, offering a synergistic approach to effectively manage DM-associated co-morbidities such as hearing impairment.
本系统评价文章旨在利用临床前动物模型评估糖尿病（DM）与感音神经性听力损失（SNHL）之间的关系。本综述重点关注评估糖尿病动物模型中 SNHL 的研究，阐明 DM 相关 SNHL 的机制，并探讨糖尿病动物模型对噪声过度暴露的反应。我们还讨论了研究潜在治疗策略对改善动物模型中 DM 相关 SNHL 的疗效的研究。
本系统评价的方案预先设计，并在 PROSPERO 数据库中注册（注册号：CRD42023439961）。我们在 PubMed、Science Direct、Web of Science、Scopus 和 EMBASE 数据库中进行了全面检索。至少有三名评审员独立筛选、选择和提取数据。使用系统评价中心进行实验室动物实验（SYRCLE）工具对合格研究进行风险偏倚评估。
经过对 238 项研究的筛选，本系统评价纳入了 12 项原始文章。这些研究表明，高血糖显著影响听觉功能，DM 诱导的听力损伤有多种病理机制，包括耳蜗突触病、微血管病变、神经病、氧化应激、线粒体异常和凋亡介导的细胞死亡。新兴干预措施，如积雪草苷、三磷酸鸟苷、绿原酸和化痰祛瘀丸，在提供耳蜗毛细胞和听力保护方面显示出有效性。
本系统评价深入探讨了动物模型中 DM 与听力损伤之间的复杂关系。未来的研究应集中于靶向治疗，以增强耳蜗线粒体功能、减轻氧化应激和调节凋亡。SNHL 与社会隔离和认知能力下降的关联突出了需要创新的治疗方法来解决尚未发现的机制。将动物模型的研究结果转化为人类研究将验证这些发现，为有效管理 DM 相关合并症（如听力损伤）提供协同方法。
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