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普遍和新发听力损失中的认知变化：马斯特里赫特衰老研究。

Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study.

机构信息

Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands.

Care and Public Health Research Institute (CAPHRI), Department of Family Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

出版信息

Alzheimers Dement. 2024 Mar;20(3):2102-2112. doi: 10.1002/alz.13606. Epub 2024 Jan 18.

DOI:10.1002/alz.13606
PMID:38236753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10984489/
Abstract

INTRODUCTION

Hearing loss (HL) has been associated with cognitive decline and dementia. We examined the temporal association between prevalent and incident HL and cognitive change.

METHODS

A total of 1823 participants (24-82 years) from the Maastricht Aging Study (MAAS) were assessed at baseline, 6 and 12 years, including pure-tone audiometry. Linear-mixed models were used to test the association between HL and cognition, adjusted for demographics and other dementia risk factors.

RESULTS

Participants with prevalent and incident HL showed a faster decline in verbal memory, information processing speed, and executive function than participants without HL. Decline was steady from baseline to 6 and 12 years for prevalent HL, but time-delayed from 6 to 12 years for incident HL. Having a hearing aid did not change associations.

DISCUSSION

Findings support the notion that HL is a risk factor for cognitive decline independent of other dementia risk factors. Onset of HL preceded onset of cognitive decline.

HIGHLIGHTS

We examined cognitive change in prevalent and incident hearing loss. Prevalent and incident hearing loss were associated with faster cognitive decline. For prevalent hearing loss, decline was steady from baseline to 6 and 12 years. Onset of hearing loss preceded the onset of cognitive decline. Having a hearing aid did not change the observed associations.

摘要

引言

听力损失（HL）与认知能力下降和痴呆有关。我们研究了现患和新发 HL 与认知变化之间的时间关联。

方法

共有 1823 名来自马斯特里赫特衰老研究（MAAS）的参与者（24-82 岁）在基线、6 年和 12 年时接受了纯音测听检查。线性混合模型用于测试 HL 与认知之间的关联，调整了人口统计学和其他痴呆风险因素。

结果

与无 HL 的参与者相比，现患和新发 HL 的参与者在言语记忆、信息处理速度和执行功能方面的下降速度更快。现患 HL 的下降从基线稳定到 6 年和 12 年，但新发 HL 的下降从 6 年延迟到 12 年。使用助听器并不能改变这些关联。

讨论

研究结果支持 HL 是独立于其他痴呆风险因素的认知能力下降的危险因素的观点。HL 的发生先于认知能力下降的发生。

要点

我们研究了现患和新发听力损失对认知变化的影响。现患和新发听力损失与认知能力下降速度加快有关。对于现患听力损失，下降从基线到 6 年和 12 年保持稳定。听力损失的发生先于认知能力下降的发生。使用助听器并不能改变观察到的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/e76c216f1231/ALZ-20-2102-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/4997851ce2e0/ALZ-20-2102-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/d492a93bae31/ALZ-20-2102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/e76c216f1231/ALZ-20-2102-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/4997851ce2e0/ALZ-20-2102-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/d492a93bae31/ALZ-20-2102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb48/10984489/e76c216f1231/ALZ-20-2102-g003.jpg

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