Waissbluth Sofia, Delano Paul H
Department of Otolaryngology, Pontificia Universidad Católica de Chile, Santiago 8330033, Chile.
Department of Neuroscience, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile.
Brain Sci. 2025 Jun 21;15(7):669. doi: 10.3390/brainsci15070669.
The aging population is increasingly affected by both diabetes mellitus and hearing loss, two conditions that often coexist and can significantly impact quality of life. As the prevalence of diabetes rises with age, so does the incidence of hearing impairment, with both conditions contributing to cognitive decline and functional limitations. The interplay between diabetes, hearing loss, and cognition highlights the need for comprehensive healthcare strategies that address the unique challenges faced by older adults. This review explores the mechanisms underlying the interplay between these three conditions, including mitochondrial dysfunction, neuroinflammation, oxidative stress, and microangiopathy.
老年人口越来越多地受到糖尿病和听力损失的影响，这两种情况经常并存，并且会显著影响生活质量。随着糖尿病患病率随年龄增长而上升，听力障碍的发生率也随之上升，这两种情况都会导致认知能力下降和功能受限。糖尿病、听力损失和认知之间的相互作用凸显了制定全面医疗保健策略的必要性，以应对老年人面临的独特挑战。本综述探讨了这三种情况之间相互作用的潜在机制，包括线粒体功能障碍、神经炎症、氧化应激和微血管病变。
